公开(公告)号：WO2022083569A1

公开(公告)日：2022-04-28

申请号：PCT/CN2021/124598

申请日：2021-10-19

Applicant: AMGEN INC. ,  ZHANG, Wenhan

Inventor： LANMAN, Brian Alan ,  BANERJEE, Abhisek ,  CHU-MOYER, Margaret ,  DAI, Dongcheng ,  ESHON, Josephine ,  HUANG, David ,  KALLER, Matthew R. ,  LEE, Heejun ,  LOPEZ, Patricia ,  MA, Vu Van ,  MANONI, Francesco ,  MEDINA, Jose M. ,  PICKRELL, Alexander J. ,  STELLWAGEN, John C. ,  SUN, Zhen ,  TAMAYO, Nuria A. ,  ZHANG, Wenhan ,  ZHU, Kai

IPC: C07D401/14 ,  C07D471/10 ,  C07D487/10 ,  A61K31/517 ,  A61P35/00

Abstract: Provided are compounds of Formula (I) having activity as inhibitors of G12C mutant KRAS protein, pharmaceutical compositions comprising the compounds, and uses and methods of treating certain disorders, such as cancer, including but not limited to lung, pancreatic and colorectal cancers.

公开(公告)号：WO2022093856A1

公开(公告)日：2022-05-05

申请号：PCT/US2021/056702

申请日：2021-10-26

Applicant: AMGEN INC.

Inventor： LANMAN, Brian Alan ,  BANERJEE, Abhisek ,  CHU-MOYER, Margaret ,  DAI, Dongcheng ,  KALLER, Matthew R. ,  LOPEZ, Patricia ,  MA, Vu Van ,  MANONI, Francesco ,  MEDINA, Jose M. ,  PICKRELL, Alexander J. ,  TAMAYO, Nuria A. ,  ZHU, Kai

IPC: A61P35/00 ,  C07D487/10 ,  C07D491/04 ,  C07D513/04 ,  A61K31/506 ,  A61K31/519 ,  A61K31/541 ,  A61K31/517 ,  A61K31/5395

Abstract: The present disclosure provides compounds of Formula (I) having activity as inhibitors of G12C mutant KRAS protein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses and methods of treating certain disorders, such as cancer, including but not limited to lung, pancreatic and colorectal cancers.