公开(公告)号：WO1991016675A1

公开(公告)日：1991-10-31

申请号：PCT/US1991002348

申请日：1991-04-04

Applicant: APPLIED BIOSYSTEMS, INC.

Inventor： APPLIED BIOSYSTEMS, INC. ,  CATHCART, G., Richard ,  BRENNAN-MARQUEZ, Thomas ,  BRIDGHAM, John, A. ,  GOLDA, George, S. ,  GUIREMAND, Harry, A. ,  HANE, Marianne ,  HOFF, Louis, Ben ,  LACHENMEIER, Eric ,  KRONICK, Melvyn, N. ,  KEITH, Douglas, H. ,  MAYRAND, Paul, Eric ,  METZKER, Michael, L. ,  MORDAN, William, J. ,  McBRIDE, Lincoln, J. ,  SHIGEURA, John ,  TING, Chen, Hanson ,  WHITELEY, Norman, M.

IPC: G01N21/01

CPC classification number: G01N35/0099 ,  B01F2215/0037 ,  B01L3/50825 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1004 ,  G01N35/109 ,  G01N2035/00079 ,  G01N2035/00237 ,  G01N2035/00356 ,  G01N2035/00435 ,  G01N2035/0403 ,  G01N2035/0475 ,  G01N2035/0491 ,  G01N2035/1013 ,  G01N2035/102 ,  G01N2035/1034 ,  G01N2035/1058 ,  G01N2035/106 ,  Y10S435/809 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: A liquid-handling instrument (11) has a worksurface (22) with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip (33) coupled to a sensing circuit, a robotic translation system (31) for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block (24) registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station (25) for the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station (21) as well as a magnetic separation station (26 and 29). Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface. A duck-billed closure (253) is disclosed for minimizing evaporation and cross-contamination during processing, and is a part of a container disclosed for storing and transporting liquids.

Abstract translation: 液体处理仪器（11）具有工作表面（22），其具有用于模块化站的配准，用于支撑液体容器，具有耦合到感测电路的吸头（33）的移液器装置，用于移动 移液器尖端和具有用于编程和编辑的标志用户界面的控制系统。 注册在工作台面上的量块（24）使用感应尖端进行校准，工作台面上的注册腔提供模块化站。 在工作台面上有一个洗手台（25）用于吸头。 基于液体处理系统的自动化实验室具有加热和冷却以及可密封的孵化站（21）以及磁分离站（26和29）。 公开了使用装置输送液体的方法，以最小的尖端污染抽吸以将容器中的液体混合并验证工作面。 公开了一种用于最小化加工期间的蒸发和交叉污染的鸭嘴盖（253），并且是用于储存和运输液体的容器的一部分。