公开(公告)号：WO2021041569A1

公开(公告)日：2021-03-04

申请号：PCT/US2020/048037

申请日：2020-08-26

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： SCOTT, David, A. ,  CHENG, David, R. ,  YAN, Winston, X. ,  DITOMMASO, Tia, M.

IPC分类号： C07K14/195 ,  C07K19/00 ,  C12N9/22

摘要： The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturaliy occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.

公开(公告)号：WO2022040224A1

公开(公告)日：2022-02-24

申请号：PCT/US2021/046360

申请日：2021-08-17

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： SCOTT, David, A. ,  CHENG, David, R. ,  YAN, Winston, X. ,  DITOMMASO, Tia, M.

IPC分类号： C12N9/22 ,  C12N15/113

摘要： The present invention relates nucleases, processes for characterizing the nucleases, compositions comprising the nucleases, and methods of using the nucleases.

公开(公告)号：WO2021050534A1

公开(公告)日：2021-03-18

申请号：PCT/US2020/049923

申请日：2020-09-09

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： SCOTT, David, A. ,  CHENG, David, R. ,  YAN, Winston, X. ,  DITOMMASO, Tia, M.

IPC分类号： A61K38/46 ,  C12N5/10 ,  C12N9/22 ,  C12N15/09 ,  C12N15/113 ,  C12N15/29

摘要： The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.