公开(公告)号：WO2021181230A1

公开(公告)日：2021-09-16

申请号：PCT/IB2021/051853

申请日：2021-03-05

Applicant: ARGA' MEDTECH SA

Inventor： WERNETH, Randell L. ,  SHERMAN, Marshall

IPC: A61B18/12 ,  A61B18/14 ,  A61K33/06 ,  A61P9/00 ,  A61K31/19 ,  A61P9/06

Abstract: The present invention relates to a method for performing non-thermal ablation, or for augmenting non- thermal ablation, of a target tissue in an organ of a patient, the method comprising: a) administering an effective amount of a composition comprising one or more calcium salts to the patient via a systemic route of administration, and b) delivering non-thermal ablative energy to the target tissue to be ablated, wherein said step a) is carried out before, during, and/or after said step b).

公开(公告)号：WO2022139797A1

公开(公告)日：2022-06-30

申请号：PCT/US2020/066444

申请日：2020-12-21

Applicant: ARGA' MEDTECH SA ,  SHERMAN, Marshall

Inventor： SHERMAN, Marshall

IPC: A61B18/12 ,  A61B18/00

Abstract: The present invention relates to an electronic apparatus (100) for delivering Coherent Sine Burst Irreversible Electroporation energy, or IRE, to a biological tissue (1) to be treated. The electronic apparatus comprises a plurality of electrodes (3) positionable either on or near the biological tissue and a power generator (2) for supplying electric energy to each of the electrodes. The power generator is configured to generate an electric signal (S) to energize each of said electrodes. This electric signal is formed by alternating over time a first electric signal (S1) with a second electric signal (S2). The first electric signal is supplied to the electrodes during a first time interval (T1) and the second electric signal is supplied to the electrodes during a second time interval (T2) subsequent to the first time interval. The first electric signal is a continuous bipolar signal comprising two or more basic sine waves (SB) in the first time interval, each basic sine wave consisting in one positive half-wave and one negative half-wave. The second electric signal has an amplitude equal to zero in said second time interval.

公开(公告)号：WO2022136464A1

公开(公告)日：2022-06-30

申请号：PCT/EP2021/087138

申请日：2021-12-21

Applicant: ARGA' MEDTECH SA ,  SHERMAN, Marshall

Inventor： SHERMAN, Marshall

IPC: A61B18/12 ,  A61B18/00

Abstract: A power unit for supplying electric energy to at least one electrode of an electronic apparatus for delivering Coherent Sine Burst Irreversible Electroporation energy, the power unit including at least one power module configured to generate an electric signal (S) to energise one or more respective electrodes, the or each power module comprising: - a selecting block configured to receive at least one square wave input signal wherein the selecting block is configured to continuously change the electric energy level associated with said electric signal (S) based on the at least one square wave input signal in order to provide a combined signal at an output of the selecting block, wherein the combined signal comprises a square wave waveform; - a filtering and electrical isolation block configured to convert the combined signal into a sine wave signal and to filter the sine wave signal to generate the electric signal (S), wherein the conversion and filtering are electrically isolated from one another.

公开(公告)号：WO2022136458A1

公开(公告)日：2022-06-30

申请号：PCT/EP2021/087130

申请日：2021-12-21

Applicant: ARGA' MEDTECH SA

Inventor： SHERMAN, Marshall

IPC: A61B18/12 ,  A61B18/00

Abstract: The present invention relates to an Electronic apparatus (100) for delivering Coherent Sine Burst Irreversible Electroporation energy to a biological tissue (1) to be treated. The electronic apparatus comprises at least one electrode (3) that is positionable either on or near the biological tissue (1) to be treated. The electronic apparatus (100) also includes a power generator (2) for supplying electric energy to the or each electrode (3), and more particularly being configured to generate a respective electric signal (S) to energize the or each individual electrode (3). The or each electric signal (S) is formed by alternating over time a first electric signal (SI) with a second electric signal (S2), with each first electric signal (SI) being the same. The first electric signal (SI) is supplied to an individual electrode (3) during a first time interval (Tl) and the second electric signal (S2) is supplied to the individual electrode (3) during a second time interval (T2), subsequent to the first time interval (Tl). The first electric signal (SI) is a continuous bipolar signal which comprises two or more basic sine waves (SB) in the first time interval (Tl). Each basic sine wave has a pea k-to- peak mean amplitude in the range 2,000 V to 20,000 V and consists of one positive half-wave and one negative half-wave, with each half-wave having the same width. The first electric signal (SI) also has a frequency in the range 25 kHz to 75 kHz. Meanwhile, the second electric signal (S2) has an amplitude equal to zero in said second time interval (T2).

公开(公告)号：WO2021181231A2

公开(公告)日：2021-09-16

申请号：PCT/IB2021/051854

申请日：2021-03-05

Applicant: ARGA' MEDTECH SA

Inventor： WERNETH, Randell L. ,  SHERMAN, Marshall

IPC: A61B18/12 ,  A61B18/14 ,  A61B5/024 ,  A61M25/01 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00351 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00726 ,  A61B2018/00732 ,  A61B2018/0075 ,  A61B2018/00767 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61B2018/1226 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126

Abstract: The present invention relates to an ablation equipment (1000) for delivering non-thermal energy, particularly Irreversible Electroporation (IRE) energy, to treat target regions of tissue (41) in organs (44). The ablation equipment (1000) comprises an ablation catheter (1) and a single power source (4). The ablation catheter (1) comprises: a catheter elongated shaft (13) comprising at least an elongated shaft distal portion (17); said catheter elongated shaft (13) comprising a flexible body (27) to navigate through body vessels (208). The ablation catheter (1) further comprises a shaft ablation assembly (20) disposed at said elongated shaft distal portion (17). The shaft ablation assembly (20) comprises at least a plurality of electrodes (3, 30, 31) fixedly disposed at said elongated shaft distal portion (17). All electrodes of said at least a plurality (3, 30, 31) are electrically connected to the single power source (4). The single power source (4) is configured to generate electric voltage signals (Sa, Sb, Va, Vb) to energize each electrode for delivering the non-thermal energy to the tissue (41) to be treated. Each of said electric voltage signals (Sa, Sb, Va, Vb) is a sinusoidal wave, and the single power source (4) is configured to supply at least a first (30) and a second (31) electrodes (30, 31) that are adjacent to each other on said ablation catheter (1), with sinusoidal electric voltage signals in phase with each other or out of phase with each other to generate a unipolar electric field and/or a bipolar electric field for delivering the non-thermal energy to the tissue (41) to be treated.