公开(公告)号：WO2023001794A1

公开(公告)日：2023-01-26

申请号：PCT/EP2022/070137

申请日：2022-07-19

申请人： ASTRAZENECA AB

发明人： NILSSON LILL, Sten ,  GIBLIN, Kathryn ,  KETTLE, Jason Grant ,  GOLDBERG, Frederick Woolf ,  GRIMSTER, Neil Patrick ,  MORRILL, Lucas ,  ESCOBAR, Randolph ,  METRANO, Anthony ,  SONG, Kun ,  SHEPPECK, James ,  ZIEGLER, Robert Evans ,  WU, Ye ,  SHA, Li ,  WU, Dedong ,  GREBE, Tyler ,  MFUH, Adelphe ,  BALAZS, Amber ,  SHIELDS, Jason

IPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D519/00 ,  A61P35/00 ,  A61K31/497

摘要： There are disclosed certain substituted pyrazine-2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly useful in the treatment or prophylaxis of cancer.