公开(公告)号：WO2018051071A9

公开(公告)日：2018-03-22

申请号：PCT/GB2017/052676

申请日：2017-09-12

申请人： BENCHMARK ANIMAL HEALTH LIMITED

发明人： SCHOLZ, Felix ,  RODGER, Hamish

IPC分类号： A61K39/395 ,  C12Q1/68 ,  C12N15/11 ,  G01N33/53

摘要： An isolated or synthetic nucleic acid from having a sequence selected from the group consisting of SEQ ID NOs: 9, 13 and 1-8, or a homologues thereof, an isolated or synthetic nucleic acid complementary to a sequence selected from the group consisting of SEQ ID NOs: 1-14, or a homologues thereof, an isolated polypeptide encoded by the nucleic acid, or an antibody that binds thereto, may be used as an immunogenic composition or diagnostic, or in a method of treatment or prevention, in respect of a microsporidian infection, in particular a Tetramicra brevifilum infection in animals, particularly fish. Additionally, methods of testing an agent for the prevention and/or treatment of a microsporidian infection, preferably a Tetramicra brevifilum infection, and kits for screening for a microsporidian infection, are provided.

公开(公告)号：WO2018051071A1

公开(公告)日：2018-03-22

申请号：PCT/GB2017/052676

申请日：2017-09-12

申请人： BENCHMARK ANIMAL HEALTH LIMITED

发明人： SCHOLZ, Felix ,  RODGER, Hamish

IPC分类号： A61K39/395 ,  C12Q1/68 ,  C12N15/11 ,  G01N33/53

CPC分类号： G01N33/56961 ,  A61K39/00 ,  A61K2039/552 ,  C12Q1/6895 ,  G01N2500/10

摘要： An isolated or synthetic nucleic acid from having a sequence selected from the group consisting of SEQ ID NOs: 9, 13 and 1-8, or a homologues thereof, an isolated or synthetic nucleic acid complementary to a sequence selected from the group consisting of SEQ ID NOs: 1-14, or a homologues thereof, an isolated polypeptide encoded by the nucleic acid, or an antibody that binds thereto, may be used as an immunogenic composition or diagnostic, or in a method of treatment or prevention, in respect of a microsporidian infection, in particular a Tetramicra brevifilum infection in animals, particularly fish. Additionally, methods of testing an agent for the prevention and/or treatment of a microsporidian infection, preferably a Tetramicra brevifilum infection, and kits for screening for a microsporidian infection, are provided.

摘要翻译： 具有选自SEQ ID NO：9,13和1-8的序列的分离的或合成的核酸，或其同源物，分离的或合成的核酸，其与 选自SEQ ID NO：1-14的序列或其同源物，由该核酸编码的分离的多肽或与其结合的抗体可以用作免疫原性组合物或诊断剂，或在方法中 对微孢子虫感染，特别是在动物特别是鱼类中感染的Tetramicra brevifilum感染的治疗或预防。 此外，还提供了用于预防和/或治疗微孢子虫感染的试剂的方法，优选地为Tetramicra brevifilum感染，以及用于筛选微孢子虫感染的试剂盒。