公开(公告)号：WO2022271962A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/034747

申请日：2022-06-23

申请人： BIOVERATIV THERAPEUTICS INC.

发明人： CARLAGE, Tyler ,  MAULDIN, Randall ,  TAZI, Loubna Mzaalak ,  MCCOY, Timothy R.

IPC分类号： A61K9/00 ,  A61K38/37 ,  C07K14/755 ,  A61K9/19 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26 ,  A61P7/04 ,  A61K47/183 ,  A61K9/0019 ,  C07K2319/30

摘要： The present disclosure provides pharmaceutical compositions of a chimeric protein comprising a factor VIII (FVIII) polypeptide and a von Willebrand factor (VWF) polypeptide. Also disclosed are pharmaceutical kits and methods of using the disclosed pharmaceutical compositions to treat hemophilia A.

公开(公告)号：WO2023064886A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/078097

申请日：2022-10-14

申请人： BIOVERATIV THERAPEUTICS INC.

发明人： CARLAGE, Tyler ,  MAULDIN, Randall ,  MCCOY, Timothy R. ,  TAZI, Loubna Mzaalak

IPC分类号： A61K9/19 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26 ,  A61P7/04 ,  A61K47/10

摘要： The present disclosure provides pharmaceutical compositions of a chimeric protein comprising a factor VIII (FVIII) polypeptide and a von Willebrand factor (VWF) polypeptide. Also disclosed are pharmaceutical kits and methods of using the disclosed pharmaceutical compositions to treat hemophilia A.