公开(公告)号：WO2023049794A1

公开(公告)日：2023-03-30

申请号：PCT/US2022/076850

申请日：2022-09-22

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： FOSTER, Stephanie, L. ,  MIRE, Chad, E. ,  CROSS, Robert, W. ,  GEISBERT, Thomas, W.

IPC: A61K39/155 ,  C07K14/115 ,  C12N15/86

Abstract: The present invention includes methods of making, compositions, or vaccinations comprising a recombinant vesicular stomatitis vims (rVSV) viral vector that expresses a Nipah Virus protein antigen, wherein the rVSV vector comprises one or more heterologous polynucleotides coding for and expressing a Nipah Virus NiVB G-protein antigen; wherein the NiVB G-protein comprises an amino acid sequence as set forth in SEQ ID NO: 6, or wherein the heterologous polynucleotide encodes a. polypeptide coding for the NiVB G-protein antigen comprising at least 90% sequence identity to an amino acid sequence as set forth in SEQ ID NO: 6, or 90% sequence identity to a nucleic acid sequence as set forth in SEQ ID NO: 2, wherein the composition or vaccine is effective to reduce or prevent a Nipah Virus infection at 3 days.