公开(公告)号：WO2013112585A1

公开(公告)日：2013-08-01

申请号：PCT/US2013/022747

申请日：2013-01-23

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： DELANEY, Joseph Thomas Jr. ,  SEETHAMRAJU, Kasyap ,  GROSSO, Paul Vincent

IPC: C07C41/16 ,  C07C67/08

CPC classification number: C07C41/01 ,  C07C41/16 ,  C07C67/08 ,  C07C43/164 ,  C07C69/76

Abstract: According to some aspects, the present disclosure pertains to methods of forming dimethyl 5- tert -butylisophthalate which comprise comprising converting 5- tert -butylisophthalic acid into dimethyl 5 -tert -butylisophthalate in synthesis procedures that comprises methanol and a dehydrating agent as chemical reagents. In other aspects, the present disclosure pertains to methods of forming 5- tert -butyl-1,3- bis (1-methoxy-l-methylethyl) benzene that comprise deprotonating 5- tert -butyl-1,3- bis (1-hydroxy-l-methylethyl)benzene with a Brønsted-Lowry superbase and methylating the deprotonated 5- tert -butyl-1,3- bis (1-hydroxy-l-methylethyl)benzene to form the 5- tert -butyl-1,3- bis (1-methoxy-l-methylethyl)benzene.

Abstract translation: 根据一些方面，本公开涉及形成5-叔丁基间苯二甲酸二甲酯的方法，其包括在包含甲醇和脱水剂作为化学试剂的合成方法中将5-叔丁基间苯二甲酸转化为5-叔丁基间苯二甲酸二甲酯。 在其它方面，本公开涉及形成5-叔丁基-1,3-双（1-甲氧基-1-甲基乙基）苯的方法，其包括将5-叔丁基-1,3-双（1- 羟基-1-甲基乙基）苯和Brnnsted-Lowry超级碱基进行甲基化，将去质子化的5-叔丁基-1,3-双（1-羟基-1-甲基乙基）苯甲基化，形成5-叔丁基-1,3 双（1-甲氧基-1-甲基乙基）苯。