公开(公告)号：WO2018183112A1

公开(公告)日：2018-10-04

申请号：PCT/US2018/024043

申请日：2018-03-23

Applicant: CARDURION PHARMACEUTICALS, LLC

Inventor： MATSUNAGA, Nobuyuki ,  NAKAHATA, Takashi ,  TANAKA, Yuta ,  TAKAHAGI, Hiroki ,  MIYAMOTO, Yasufumi ,  OKAMOTO, Rei ,  YOSHIKAWA, Takeshi ,  TERAO, Yoshito ,  YUKAWA, Takafumi ,  KAKEGAWA, Keiko ,  NISHIKAWA, Youichi ,  TAKAGI, Terufumi ,  TAKAHASHI, Masashi ,  KOMANDLA, Mallareddy ,  KWOK, Lily ,  MIURA, Joanne ,  SABAT, Mark ,  SCORAH, Nicholas ,  TANIS, Paul ,  TYHONAS, John ,  VU, Phong H. ,  WANG, Haixia ,  WANG, Xiaolun ,  SHIRAI, Junya ,  OKAWA, Tomohiro ,  SHIOKAWA, Zenyu ,  SHIBUYA, Akito

IPC: A61K31/506 ,  C07D239/28

Abstract: The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I), wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：WO2022067082A1

公开(公告)日：2022-03-31

申请号：PCT/US2021/052025

申请日：2021-09-24

Applicant: CARDURION PHARMACEUTICALS, LLC

Inventor： MATSUNAGA, Nobuyuki ,  SHIRAI, Junya ,  OKAWA, Tomohiro ,  MIYAMOTO, Yasufumi ,  SHIOKAWA, Zenyu ,  NAKAHATA, Takashi ,  SHIBUYA, Akito ,  KAWADA, Akira ,  MACCOSS, Malcolm

IPC: A61K31/41 ,  A61K31/4192 ,  A61K31/495 ,  C07D257/04 ,  C07D257/10 ,  C07D403/14

Abstract: The present invention provides a fused heteroaryl compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.

公开(公告)号：WO2020068854A1

公开(公告)日：2020-04-02

申请号：PCT/US2019/052730

申请日：2019-09-24

Applicant: CARDURION PHARMACEUTICALS, LLC

Inventor： MATSUNAGA, Nobuyuki ,  MIYAMOTO, Yasufumi ,  SHIRAI, Junya ,  NAKAHATA, Takashi ,  SHIOKAWA, Zenyu ,  OKAWA, Tomohiro ,  SHIBUYA, Akito ,  MACCOSS, Malcolm

IPC: A61K31/506 ,  C07D239/28 ,  A61P9/06

Abstract: The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.