公开(公告)号：WO2021181221A1

公开(公告)日：2021-09-16

申请号：PCT/IB2021/051814

申请日：2021-03-04

Applicant: CELLIDO THERAPEUTICS B.V.

Inventor： DRUKKER, Micha ,  GROSCH, Markus Oliver

IPC: A61K31/00 ,  A61K31/136 ,  A61K31/407 ,  A61K31/453 ,  A61K31/538 ,  A61K31/704 ,  A61K31/7048 ,  A61K38/08 ,  A61P9/00 ,  A61P25/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  G01N33/50

Abstract: The present disclosure describes compounds that can promote the disintegration of complexes containing long non-coding RNA (lncRNA) in vivo. The present disclosure provides a method of using small molecules to treat human diseases, wherein the small molecules are used to disintegrate nuclear condensates comprising lncRNAs. Further, the present disclosure provides an in vitro method of identifying small molecules for the treatment of human diseases associated with lncRNA.