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公开(公告)号：WO2022125392A1
公开(公告)日：2022-06-16
申请号：PCT/US2021/061781
申请日：2021-12-03
发明人： WANG, Benjamin , ZEINER, Gusti
摘要： Methods and compositions for reducing Notch inhibition of T-cell activation are disclosed. Also, disclosed are RDEs which can be used to optimize expression of transgenes, e.g., CARs, in a eukaryotic cells so that, for example, effector function is optimized. CARs and transgene payloads can also be engineered into eukaryotic cells so that the transgene payload is expressed and delivered at desired times from the eukaryotic cell. Such CAR T-cells with transgene payloads can be combined with the administration of other molecules, e.g., other therapeutics such as anti cancer therapies.
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