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1.发明申请B-VITAMIN AND AMINO ACID CONJUGATES OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, DERIVATIVES THEREOF, AND METHODS OF PREPARATION THEREOF 审中-公开烟酰胺核糖核苷和还原的烟酰基核糖核苷的B-维生素和氨基酸的偶联物，其衍生物及其制备方法
公开(公告)号：WO2017161165A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022779
申请日：2017-03-16
Applicant: CHROMADEX INC. , THE QUEEN'S UNIVERSITY OF BELFAST
Inventor： MIGAUD, Marie, Eugenie , REDPATH, Philip , CROSSEY, Kerri , CUNNINGHAM, Richard , DELLINGER, Ryan , RHONEMUS, Troy , VENKATARAMAN, Sylesh , NETTLES, Brian
Abstract: The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): wherein X - , Z 1 Z 2 , n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are described herein, reduced analogs thereof, and synthetic processes for the preparation thereof.
Abstract translation: 本公开提供了烟酸酯/烟酰胺核糖核苷化合物或式（I）的衍生物：其中X 1，Z 1 Z Z 2 n，R 1，R 2，R 3，R 4，R 5，R 4，R 4，R 4，R 4， 本文描述了R 5，R 6，R 7和R 8，它们的还原类似物，以及用于 准备。
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公开(公告)号：WO2016196941A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035729
申请日：2016-06-03
Applicant: CHROMADEX, INC. , THE QUEEN'S UNIVERSITY OF BELFAST
Inventor： MIGAUD, Marie Eugenie , REDPATH, Philip , CROSSEY, Kerri , CUNNINGHAM, Richard , RHONEMUS, Troy , VENKATARAMAN, Sylesh
CPC classification number: C07H19/048 , C07F9/582 , C07F9/65583 , C07F9/65616 , C07H1/04 , C07H19/04 , C07H19/20
Abstract: A synthetic process is provided for the preparation of phosphorylated analogs of nicotinamide riboside ("NR") having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II), wherein X - , Y 1 , Y 2 , Z 1 , Z 2 , n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as defined herein. The present disclosure also relates to the preparation of phosphorylated analogs of nicotinic acid riboside ("NAR") having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II). Generally solvent-free conditions are employed using appropriate mechano-chemical techniques as described. (I) (II)
Abstract translation: 提供了一种合成方法，用于制备具有式（I）的烟酰胺核苷（“NR”）或其盐以及具有式（II）的还原或修饰的衍生物的磷酸化类似物，其中X，Y 1， Y2，Z1，Z2，n，R1，R2，R3，R4，R5，R6和R7如本文所定义。 本公开还涉及具有式（I）的烟酸核糖苷（“NAR”）的磷酸化类似物或其盐以及具有式（II）的还原或修饰的衍生物的制备。 一般使用无溶剂条件，使用所述的适当的机械化学技术。 （一）（二）
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