公开(公告)号：WO2014052799A1

公开(公告)日：2014-04-03

申请号：PCT/US2013/062256

申请日：2013-09-27

Applicant: CUBIST PHARMACEUTICALS, INC.

Inventor： LAI, Jan-Ji ,  GU, Jian-Qiao ,  PATHARE, Pradip, M. ,  JURKAUSKAS, Valdas ,  TERRACCIANO, Joseph ,  MILLER DAMOUR, Nicole

IPC: A61K31/546 ,  A61K31/431 ,  A61K9/19 ,  A61P31/04

CPC classification number: A61K31/431 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/155 ,  A61K31/546 ,  A61K45/06 ,  A61K2300/00

Abstract: This disclosure provides compositions comprising a beta- lactam compound and crystalline tazobactam arginine, and related methods and uses of these compositions.

Abstract translation: 本公开提供了包含β-内酰胺化合物和结晶他唑巴坦精氨酸的组合物，以及这些组合物的相关方法和用途。

公开(公告)号：WO2002059145A1

公开(公告)日：2002-08-01

申请号：PCT/US2001/048886

申请日：2001-12-17

Applicant: CUBIST PHARMACEUTICALS, INC. ,  KEITH, Dennis ,  LAI, Jan-Ji

Inventor： KEITH, Dennis ,  LAI, Jan-Ji

IPC: C07K7/64

CPC classification number: C07K7/08 ,  A61K38/00

Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.

Abstract translation: 本发明涉及结晶和晶体样形式的脂肽，包括达托霉素，对革兰氏阳性细菌具有强效杀菌活性的脂肽抗生素，包括对常规抗生素具有抗性的菌株。 本发明涉及纯化脂肽的方法，包括达托霉素，对革兰氏阳性菌具有强效杀菌活性的脂肽抗生素，包括对常规抗生素具有抗性的菌株。 本发明还涉及包含纯化形式的脂肽的药物组合物和使用这些组合物的方法。

公开(公告)号：WO2001053330A3

公开(公告)日：2001-07-26

申请号：PCT/US2001/001748

申请日：2001-01-18

Applicant: CUBIST PHARMACEUTICALS, INC. ,  KELLEHER, Thomas, J. ,  LAI, Jan-Ji ,  DECOURCEY, Joseph, P. ,  LYNCH, Paul, D. ,  ZENONI, Maurizio ,  TAGLIANI, Auro, R.

Inventor： KELLEHER, Thomas, J. ,  LAI, Jan-Ji ,  DECOURCEY, Joseph, P. ,  LYNCH, Paul, D. ,  ZENONI, Maurizio ,  TAGLIANI, Auro, R.

IPC: C07K7/08

Abstract: The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of Streptomyces roseosporus . The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.