公开(公告)号：WO2023283453A1

公开(公告)日：2023-01-12

申请号：PCT/US2022/036569

申请日：2022-07-08

Applicant: DICE ALPHA, INC.

Inventor： REILLY, Maureen ,  FATHEREE, Paul R. ,  AQUINO, Claudio ,  FREIDBERG, Michael ,  CHURCH, Timothy J.

IPC: A61P29/00 ,  C07D213/56 ,  C07D231/14 ,  C07D261/18 ,  C07D271/08 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

Abstract: The disclosure herein provides phenyl acetamide based compounds of Formula (I), (I-a), (II), and pharmaceutical compositions thereof, for the modulation of IL-17A, useful in the treatment of inflammatory conditions such as psoriasis.

公开(公告)号：WO2021055376A1

公开(公告)日：2021-03-25

申请号：PCT/US2020/050924

申请日：2020-09-15

Applicant: DICE ALPHA, INC.

Inventor： FATHEREE, Paul R. ,  LINSELL, Martin S. ,  JACOBSEN, John R. ,  VAN DER LINDEN, Wouter A. ,  CHURCH, Timothy J. ,  AQUINO, Claudio ,  PAULICK, Margot G.

IPC: C07D241/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D491/048 ,  C07D493/04 ,  C07D495/04 ,  A61K31/496 ,  A61P35/00

Abstract: The disclosure herein provides compounds and pharmaceutical compositions for the modulation of IL-17A useful for the treatment of inflammatory conditions, such as psoriasis.

公开(公告)号：WO2020163554A1

公开(公告)日：2020-08-13

申请号：PCT/US2020/016925

申请日：2020-02-06

Applicant: DICE ALPHA, INC.

Inventor： FATHEREE, Paul R. ,  LINSELL, Martin S. ,  JACOBSEN, John R. ,  VAN DER LINDEN, Wouter ,  CHURCH, Timothy J. ,  AQUINO, Claudio ,  PAULICK, Margot

IPC: A61P35/00 ,  A61K31/4155 ,  A61K31/5377 ,  A61P37/00 ,  C07D231/38 ,  C07D279/12 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

Abstract: Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.