公开(公告)号：WO0210116A3

公开(公告)日：2002-05-10

申请号：PCT/US0122704

申请日：2001-07-19

Applicant: EASTMAN CHEM CO

Inventor： HUBBS JOHN CLARK ,  ATTRIDE DAVID CARL ,  BOAZ NEIL WARREN ,  CIULA JAMES CHARLES ,  MADDOX JOHN THORTON ,  NABIH THOMAS ,  NOTTINGHAM WILLIAM DELL ,  SPENCER DAVID CHRIS

IPC: C07C67/00 ,  C07C67/307 ,  C07C67/317 ,  C07C209/56 ,  C07C211/35 ,  C07C69/74 ,  C07C69/63

CPC classification number: C07C209/56 ,  C07C67/00 ,  C07C67/307 ,  C07C67/317 ,  C07C2601/02 ,  C07C69/74 ,  C07C69/63 ,  C07C211/35

Abstract: Disclosed is a 4-step process for the preparation of alkyl esters of 1-methylcyclopropanecarboxylic acid which comprises the steps of (1) converting gamma -butyrolactone to alpha -methyl- gamma -butyrolactone; (2) converting the alpha -methyl- gamma -butyrolactone from step (1) to an alkyl 4-halo-2-methyl-butyrate; (3) producing a xylene solution of the alkyl 4-halo-2-methyl-butyrate; and (4) contacting the xylene solution of the alkyl 4-halo-2-methylbutyrate from step (3) with an alkali metal alkoxide under conditions to temperature and pressure which causes vaporization of (i) an alkanol as it is fomred and (ii) an alkyl 1-methylcyclopropanecarboxylate as it si formed from the alkyl 4-halo-2-methylbutyrate. Also disclosed are processes whereby the alkyl 1-methylcyclopropanecarboxylate, prepared as described above, is converted to 1-methylcyclopropylamine.

Abstract translation: 公开了用于制备1-甲基环丙烷羧酸的烷基酯的4步方法，其包括以下步骤：（1）将γ-丁内酯转化为α-甲基-γ-丁内酯; （2）将步骤（1）中的α-甲基-γ-丁内酯转化为4-卤代-2-甲基 - 丁酸烷基酯; （3）生产4-卤代-2-甲基 - 丁酸烷基酯的二甲苯溶液; 和（4）在步骤（3）的4-卤代-2-甲基丁酸烷基酯的二甲苯溶液与碱金属醇盐的温度和压力相接触的条件下，使得（i）当链烷醇被蒸发时， ）一种由4-卤代-2-甲基丁酸烷基形成的1-甲基环丙烷羧酸烷基酯。 还公开了将如上所述制备的1-甲基环丙烷羧酸烷基酯转化成1-甲基环丙胺的方法。