公开(公告)号：WO2016106160A1

公开(公告)日：2016-06-30

申请号：PCT/US2015/066955

申请日：2015-12-19

Applicant: ENUMERAL BIOMEDICAL HOLDINGS, INC.

Inventor： TINKELENBERG, Arthur, H. ,  NGUYEN, Anhco ,  CHIU, Maria, Isabel ,  JONCA, Aleksander ,  MCQUADE, Thomas ,  VADDE, Sri, Sahitya ,  RANGANATH, Sheila

IPC: G01N33/50 ,  G01N33/68

CPC classification number: G01N33/5023 ,  G01N33/5047 ,  G01N33/6854 ,  G01N2333/52 ,  G01N2333/535 ,  G01N2333/54 ,  G01N2333/57 ,  G01N2333/70514 ,  G01N2333/70517 ,  G01N2333/70596

Abstract: Methods of selecting test compounds on the basis of their cellular response profiles are disclosed. For a given test compound, a cellular response is determined by introducing into an array of individually addressable microwells a population of cells comprising a plurality of cell types and contacting the cells with the test compound. The cellular response profile for the test compound is then compared to a desired cellular response profile, and the test compound is selected based on the comparison.

Abstract translation: 公开了根据其细胞反应特征选择测试化合物的方法。 对于给定的测试化合物，通过将包含多种细胞类型并将细胞与测试化合物接触的细胞群体引入单独可寻址的微孔阵列来确定细胞应答。 然后将测试化合物的细胞反应特征与期望的细胞反应谱比较，并且基于比较选择测试化合物。