公开(公告)号：WO2021259815A1

公开(公告)日：2021-12-30

申请号：PCT/EP2021/066725

申请日：2021-06-21

申请人： F. HOFFMANN-LA ROCHE AG ,  HOFFMANN-LA ROCHE INC.

发明人： BELL, Andrew Simon ,  BESNARD, Jérémy ,  BRADLEY, Anthony Richard ,  GREEN, Luke ,  HAAP, Wolfgang ,  KOCER, Buelent ,  KUGLSTATTER, Andreas ,  LUCAS, Xavier ,  MATTEI, Patrizio ,  MAZUNIN, Dmitry ,  RATNI, Hasane ,  RIEMER, Claus ,  VAN HOORN, Willem Paul

IPC分类号： C07D239/95 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D417/04 ,  C07D471/04 ,  C07D473/04 ,  A61P35/00 ,  A61K31/00

摘要： The present invention provides compounds of formula I or II: wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

公开(公告)号：WO2022162034A1

公开(公告)日：2022-08-04

申请号：PCT/EP2022/051823

申请日：2022-01-27

申请人： F. HOFFMANN-LA ROCHE AG ,  HOFFMANN-LA ROCHE INC.

发明人： BELL, Andrew Simon ,  BESNARD, Jérémy ,  BRADLEY, Anthony Richard ,  GREEN, Luke ,  HAAP, Wolfgang ,  KOCER, Buelent ,  KUGLSTATTER, Andreas ,  LUCAS, Xavier ,  MATTEI, Patrizio ,  MAZUNIN, Dmitry ,  RIEMER, Claus ,  VAN HOORN, Willem Paul

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61P35/00

摘要： The present invention provides compounds of formula I or II: (I) wherein X1, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

公开(公告)号：WO2021259831A1

公开(公告)日：2021-12-30

申请号：PCT/EP2021/066767

申请日：2021-06-21

申请人： F. HOFFMANN-LA ROCHE AG ,  HOFFMANN-LA ROCHE INC.

发明人： BELL, Andrew, Simon ,  BESNARD, Jérémy ,  BRADLEY, Anthony, Richard ,  GREEN, Luke ,  HAAP, Wolfgang ,  KOCER, Buelent ,  KUGLSTATTER, Andreas ,  LUCAS, Xavier ,  MATTEI, Patrizio ,  MAZUNIN, Dmitry ,  RIEMER, Claus ,  VAN HOORN, Willem Paul

IPC分类号： C07D231/56 ,  C07D487/04 ,  A61P35/00 ,  A61K31/416

摘要： The present invention provides compounds of formula (I) wherein X1, X2, X3, X4, R1, R1a, R1b, R2', R2", R3', R3", R6 and R7 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.