公开(公告)号：WO2023288299A1

公开(公告)日：2023-01-19

申请号：PCT/US2022/073769

申请日：2022-07-15

Applicant: FARBER PARTNERS, LLC

Inventor： OLSZEWSKI, Kellen ,  RABINOWITZ, Joshua, D. ,  KIM, Hahn

IPC: A61K31/045 ,  A61K39/395 ,  A61P35/00 ,  C07C41/00

Abstract: Provided herein are methods of using methanol, or a prodrug thereof, in therapy, e.g., for promoting an immune response, treating cancer, enhancing an immunotherapy and/or treating immune dysfunction. Also provided herein are methanol prodrugs of the following structural formula: Formula (I), or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., R, X, R2, n) are as described herein.