公开(公告)号：WO2013147793A1

公开(公告)日：2013-10-03

申请号：PCT/US2012/031213

申请日：2012-03-29

Applicant: FLEMING, Robert, J. ,  ARTAVANIS-TSAKONAS, Spyridon

Inventor： FLEMING, Robert, J. ,  ARTAVANIS-TSAKONAS, Spyridon

IPC: A61P35/00 ,  A61K39/395 ,  C07K14/00

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/43581 ,  C07K16/28 ,  C07K2317/30 ,  C07K2317/76 ,  C07K2319/30

Abstract: Provided herein are polypeptides and derivatives thereof that contain sequences of a Serrate protein and that inhibit Notch pathway function. Also provided herein are nucleic acids that encode the polypeptides, vectors and cells for producing the polypeptides, and related pharmaceutical compositions and kits. Additionally provided are antibodies which bind to the Notch inhibitory region of a Serrate protein. Therapeutic methods are also provided.

Abstract translation: 本文提供含有Serrate蛋白序列并抑制Notch途径功能的多肽及其衍生物。 本文还提供了编码多肽的核酸，用于产生多肽的载体和细胞，以及相关的药物组合物和试剂盒。 另外提供了结合丝氨酸蛋白的Notch抑制区的抗体。 还提供了治疗方法。

公开(公告)号：WO2004017700A1

公开(公告)日：2004-02-26

申请号：PCT/US2003/025660

申请日：2003-08-15

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  FUNKENBUSCH, Arnold, W. ,  BRIGHT, Clark, I. ,  FLEMING, Robert, J.

Inventor： FUNKENBUSCH, Arnold, W. ,  BRIGHT, Clark, I. ,  FLEMING, Robert, J.

IPC: H05K9/00

CPC classification number: H05K9/0094 ,  Y10T428/12396 ,  Y10T428/12569 ,  Y10T428/12896 ,  Y10T428/13 ,  Y10T428/24967 ,  Y10T428/24975 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/31678 ,  Y10T428/31688 ,  Y10T428/31692

Abstract: A device or an enclosed area that can cause or is sensitive to electromagnetic interference (EMI) is shielded by at least partially surrounding the device or the area with a visible light-transmissive film comprising a flexible support, an extensible visible light-transmissive metal or metal alloy layer and a visible light-transmissive crosslinked polymeric protective layer, and optionally connecting at least one grounding electrode to the metal or metal alloy layer. The film has reduced susceptibility to fracture or corrosion compared to commercially available EMI shielding films, especially when bent or deformed.

Abstract translation: 可以对电磁干扰（EMI）造成或者敏感的装置或封闭区域被至少部分地围绕该装置或具有可见光透射膜的区域屏蔽，所述可见光透射膜包括柔性支撑件，可延伸的可见光透射金属或 金属合金层和可见光透射交联聚合物保护层，并且可选地将至少一个接地电极连接到金属或金属合金层。 与市售的EMI屏蔽膜相比，该膜具有降低的断裂或腐蚀的易感性，特别是当弯曲或变形时。