专利检索 ap:("GENENTECH, INC.") AND inv:"HUANG, Jian" 第 1 页

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发明申请
COMBINATION THERAPIES FOR TREATMENT OF BREAST CANCER 审中-公开

公开(公告)号：WO2021113219A1

公开(公告)日：2021-06-10

申请号：PCT/US2020/062673

申请日：2020-12-01

申请人： GENENTECH, INC.

发明人： LAUCHLE, Jennifer O'Hara , MAMOUNAS, Michael Joseph , SCHUTZMAN, Jennifer Lee , FRIEDMAN, Lori Sickels , HUANG, Jian

IPC分类号： A61K31/41 , A61K31/519 , A61K31/553 , A61K31/5685 , A61P35/00

摘要： Provided are combination therapies comprising a PI3K inhibitor (e.g., inavolisib), a CDK4/6 inhibitor (e.g., palbociclib), and fulvestrant; and methods of treating hormone receptor positive and HER2 negative (HR+/HER2-) locally advanced or metastatic breast cancer in a patient (preferably a patient with a PIC3CA mutant patient) comprising administering a therapeutically effective amount of inavolisib, or a pharmaceutically acceptable salt thereof, a CDK4/6 inhibitor (e.g., palbociclib), and fulvestrant or letrozole.