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1.ANTIGEN BINDING COMPLEX HAVING AGONISTIC ACTIVITY AND METHODS OF USE 审中-公开
标题翻译: 具有激活活性的抗原结合复合物及其使用方法公开(公告)号:WO2016164480A1
公开(公告)日:2016-10-13
申请号:PCT/US2016/026245
申请日:2016-04-06
发明人: LAZAR, Greg , KIM, Jeong , ZHU, Jing , YANG, Yanli , BREZSKI, Randall
CPC分类号: C07K16/2875 , A61K38/02 , A61K39/395 , A61K47/6881 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/622 , C07K2317/71 , C07K2317/73 , C07K2317/75 , C07K2317/92
摘要: Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or polypeptides having agonist activity, enhancing the agonist activity of a polypeptide, and for agonizing a cell surface receptor using the complexes and polypeptide described herein.
摘要翻译: 本文提供具有激动剂活性的抗原结合多肽及其复合物。 还提供了筛选具有激动剂活性的复合物或多肽,增强多肽的激动剂活性以及使用本文所述的复合物和多肽刺激细胞表面受体的方法。
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2.COMBINATION THERAPY COMPRISING ANTI-ANGIOGENESIS AGENTS AND OX40 BINDING AGONISTS 审中-公开
标题翻译: 包含抗血管发生剂和OX40结合激素的联合治疗公开(公告)号:WO2015153514A1
公开(公告)日:2015-10-08
申请号:PCT/US2015/023434
申请日:2015-03-30
发明人: WALSH, Kevin , DE ALMEIDA, Patricia , DU, Changchun , KIM, Jeong , ZHU, Jing , BEVERS, Jack , ANDYA, James , SHEN, Ye
IPC分类号: C07K16/22 , C07K16/28 , A61P35/00 , A61K39/395
CPC分类号: C07K16/2878 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要: The disclosure provides compositions and methods for treating cancers. The method comprises administering an anti-angiogenesis agent and an OX40 binding agonist.
摘要翻译: 本公开提供了治疗癌症的组合物和方法。 该方法包括施用抗血管生成剂和OX40结合激动剂。
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公开(公告)号:WO2015153513A1
公开(公告)日:2015-10-08
申请号:PCT/US2015/023432
申请日:2015-03-30
发明人: DU, Changchun , KIM, Jeong , ZHU, Jing , BEVERS, Jack , WALSH, Kevin , DE ALMEIDA, Patricia , ANDYA, James , SHEN, Ye
IPC分类号: C07K16/28
CPC分类号: C07K16/2878 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/70 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The disclosure provides anti-OX40 antibodies and methods of using the same.
摘要翻译: 本公开提供了抗OX40抗体及其使用方法。
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