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1.发明申请MOLECULES WITH BIMODAL ACTIVITY DEPLETING TARGET AT LOW DOSE AND INCREASING IMMUNOSUPPRESSION AT HIGHER DOSE 审中-公开具有双重活性的分子在低剂量下降低目标并在更高剂量下增加免疫抑制
公开(公告)号：WO2016073917A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/059574
申请日：2015-11-06
Applicant: GLIKNIK INC. , UNIVERSITY OF MARYLAND, BALTIMORE
Inventor： BLOCK, David S. , OLSEN, Henrik , STROME, Scott , ZHANG, Xiaoyu
IPC: A61K39/395
CPC classification number: C07K16/2887 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2039/577 , C07K16/32 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/55 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/73
Abstract: The present disclosure involves biologically active proteins termed stradobodies and having bimodal activity. Thus, the present disclosure provides compositions and methods providing both target cell destructive and immunosuppressive activities, useful in the treatment of diseases and conditions including autoimmune diseases, inflammatory diseases, infectious diseases, or cancers.
Abstract translation: 本公开涉及称为晶状体并具有双峰活性的生物活性蛋白。 因此，本公开提供了提供靶细胞破坏性和免疫抑制活性两者的组合物和方法，其可用于治疗包括自身免疫疾病，炎性疾病，感染性疾病或癌症在内的疾病和病症。
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2.发明申请FUSION PROTEINS OF HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN FC COMPOSITIONS WITH ENHANCED FC RECEPTOR BINDING 审中-公开人类蛋白片段的融合蛋白创造有序多种免疫球蛋白FC组合物与增强的FC受体结合
公开(公告)号：WO2018018047A3
公开(公告)日：2018-01-25
申请号：PCT/US2017/043538
申请日：2017-07-24
Applicant: GLIKNIK INC.
Inventor： BLOCK, David S. , OLSEN, Henrik
IPC: A61K39/395 , A61K45/06 , C07K14/47
Abstract: The present invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. The invention involves fusion proteins that bind to FcγRs and complement and that are useful in the treatment and prevention of disease.
Abstract translation: 本发明涉及一系列完全重组的多聚形式的免疫球蛋白Fc，其由此将多价免疫球蛋白Fc呈递给免疫细胞受体。 融合蛋白作为同型二聚体和高度有序的多聚体部分存在，被称为连接体。 本发明涉及与FcγR和补体结合并可用于治疗和预防疾病的融合蛋白。
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公开(公告)号：WO2021263128A1
公开(公告)日：2021-12-30
申请号：PCT/US2021/039131
申请日：2021-06-25
Applicant: GLIKNIK INC.
Inventor： BLOCK, David S. , OLSEN, Henrik
Abstract: The present disclosure provides ACE2-Fc fusion proteins comprising an ACE2 extracellular domain or fragment thereof and one or more Fc domains and methods of use thereof.
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公开(公告)号：WO2018107082A1
公开(公告)日：2018-06-14
申请号：PCT/US2017/065400
申请日：2017-12-08
Applicant: GLIKNIK INC.
Inventor： BLOCK, David S. , OLSEN, Henrik
Abstract: The present invention provides methods for the identification of patients with an inflammatory or autoimmune disease that demonstrate an inadequate response to treatment with a multi-Fc therapeutic, and the determination of an optimal dose of a multi-Fc therapeutic for said patient based on the patient's circulating levels of inactivated C3b (iC3b) and/or additional complement components that may be employed as a surrogate for iC3b based on an analogous response to multi-Fc therapeutics. The present invention further provides for improvements in the use of such multi-Fc therapeutics in the treatment of autoimmune and inflammatory diseases
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公开(公告)号：WO2018018047A2
公开(公告)日：2018-01-25
申请号：PCT/US2017/043538
申请日：2017-07-24
Applicant: GLIKNIK INC.
Inventor： BLOCK, David S. , OLSEN, Henrik
Abstract: The present invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. The invention involves fusion proteins that bind to FcγRs and complement and that are useful in the treatment and prevention of disease.
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Patent Agency Ranking
公开(公告)号：WO2017214321A1
公开(公告)日：2017-12-14
申请号：PCT/US2017/036425
申请日：2017-06-07
Applicant: GLIKNIK INC.
Inventor： OLSEN, Henrik , BLOCK, David S.
IPC: C07K16/00 , C07K16/46 , A61K39/395
Abstract: The present disclosure involves biologically active proteins termed cysteine-optimized multimerizing stradomers. Thus, the present disclosure provides compositions and methods providing anti-autoimmune and anti-inflammatory activities, useful in the treatment of diseases and conditions including autoimmune diseases, inflammatory diseases, or infectious diseases.
Abstract translation: 本公开涉及称为半胱氨酸优化的多聚体稳定剂的生物活性蛋白质。 因此，本公开内容提供了提供抗自身免疫和抗炎活性的组合物和方法，其可用于治疗疾病和病症，包括自身免疫性疾病，炎症性疾病或感染性疾病。
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7.发明申请FUSION PROTEINS OF NATURAL HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN FC COMPOSITIONS 审中-公开天然人蛋白质片段的融合蛋白创造有序多种免疫球蛋白FC组合物
公开(公告)号：WO2012016073A2
公开(公告)日：2012-02-02
申请号：PCT/US2011/045768
申请日：2011-07-28
Applicant: GLIKNIK INC. , BLOCK, David S. , OLSEN, Henrik
Inventor： BLOCK, David S. , OLSEN, Henrik
IPC: A61K39/395
CPC classification number: C07K14/47 , A61K31/573 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/00 , C07K2317/35 , C07K2317/52 , C07K2317/92 , C07K2319/30 , C07K2319/73 , C07K2319/735 , A61K2300/00
Abstract: The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. In comparison to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for Fc Rs with slower dissociation and are useful in the treatment and prevention of disease. The current invention demonstrates that directly linking IgG1 Fc regions to multimerization domains leads to enhanced multimerization and biological activity.
Abstract translation: 本发明涉及一系列完全重组的多聚化形式的免疫球蛋白Fc，其由此将多价免疫球蛋白Fc呈递给免疫细胞受体。 融合蛋白作为同型二聚体和高度有序的多聚体部分存在，被称为连接体。 与同二聚体级分相比，纯化的多聚体立体异构体对FcR具有较高的亲和力和较高的解离率，可用于治疗和预防疾病。 本发明证明将IgG1 Fc区直接连接到多聚化结构域导致增强的多聚化和生物活性。
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公开(公告)号：WO2018107079A1
公开(公告)日：2018-06-14
申请号：PCT/US2017/065397
申请日：2017-12-08
Applicant: GLIKNIK INC.
Inventor： BLOCK, David S. , MÉRIGEON, Emmanuel Y. , OLSEN, Henrik
IPC: C07K14/47 , C07K16/18 , C07K16/28 , C07K16/32 , C07K16/46 , C07K1/14 , A61K39/395 , A61K47/64 , C12P21/08
Abstract: The present disclosure involves optimized methods for production of hiologically active proteins termed optimally manufactured stradomers. The present disclosure further provides compositions and methods useful in the treatment of diseases and conditions including autoimmune diseases, inflammatory diseases, or infectious diseases.
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9.发明申请FUSION PROTEINS OF HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN FC COMPOSITIONS WITH ENHANCED COMPLEMENT BINDING 审中-公开人类蛋白质片段的融合蛋白产生具有增强的补体结合的有序多功能的免疫球蛋白FC组合物
公开(公告)号：WO2017019565A2
公开(公告)日：2017-02-02
申请号：PCT/US2016/043746
申请日：2016-07-22
Applicant: GLIKNIK INC.
Inventor： BLOCK, David S. , OLSEN, Henrik
IPC: A61K47/48 , A61K39/395
CPC classification number: C07K16/00 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/94 , C07K2319/00
Abstract: The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. The invention involves stradomers that increase multimerization and bind preferentially to complement and that are useful in the treatment and prevention of disease.
Abstract translation: 本发明涉及一系列完全重组的多聚体形式的免疫球蛋白Fc，由此向免疫细胞受体提供多价免疫球蛋白Fc。 融合蛋白以同二聚体和高度有序的多聚体级分存在，称为交联体。 本发明涉及增加多聚化并优先结合于补体并且可用于治疗和预防疾病的相互作用体。
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公开(公告)号：WO2013112986A1
公开(公告)日：2013-08-01
申请号：PCT/US2013/023404
申请日：2013-01-28
Applicant: GLIKNIK INC.
Inventor： BLOCK, David , OLSEN, Henrik
IPC: C07K19/00
CPC classification number: C07K16/00 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K14/46 , C07K14/5434 , C07K14/62 , C07K14/635 , C07K14/70503 , C07K14/70521 , C07K14/70539 , C07K14/7155 , C07K16/2863 , C07K16/32 , C07K2317/41 , C07K2317/52 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/71 , C07K2319/00 , C07K2319/30 , C07K2319/31 , C07K2319/55 , C07K2319/60
Abstract: The present invention relates to biologically active fusion proteins containing the IgG2 hinge as a multimerization domain capable of multimerizing proteins, peptides and small molecules which are active or more active in multimeric form; compositions comprising such fusion proteins; and methods of making and using such fusion proteins.
Abstract translation: 本发明涉及含有IgG2铰链作为多聚化结构域的生物活性融合蛋白，能够多聚化多聚体形式的活性或更有活性的蛋白质，肽和小分子; 包含这种融合蛋白的组合物; 以及制备和使用这种融合蛋白的方法。
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