公开(公告)号：WO2018049216A1

公开(公告)日：2018-03-15

申请号：PCT/US2017/050759

申请日：2017-09-08

Applicant: GLYKON TECHNOLOGIES GROUP, LLC

Inventor： CLOUATRE, Daniel E. ,  BANGUN, Nimpan ,  CLOUATRE, Dallas L.

IPC: A61K31/19 ,  A61K31/185 ,  A61K31/194 ,  C07C59/235 ,  C07C59/245 ,  C07C59/265

Abstract: Monomeric bimetal hydroxycitric acid (HCA) compounds are provided. The subject compounds include a divalent metal (X) bonded to the carboxylic acids of C2 and C3 and a monovalent metal (Y) bonded to the carboxylic acid of C1. Also provided are methods of preparing the subject compounds from a dimeric starting material (e.g., X3(HCA)2) which include acidifying the dimer to produce a monomeric intermediate which is subsequently neutralized with YOH base. Methods of alleviating at least one symptom associated with a target disease or condition in a subject are provided. Also provided are compositions including the subject monomeric bimetal HCA compounds which find use in a variety of therapeutic applications.

Abstract translation: 提供了单体双金属羟基柠檬酸（HCA）化合物。 主题化合物包括与C2和C3的羧酸键合的二价金属（X）和与C1的羧酸键合的单价金属（Y）。 还提供了从二聚原料（例如X3（HCA）2）制备主题化合物的方法，其包括酸化二聚体以产生随后用YOH碱中和的单体中间体。 提供了减轻受试者中与目标疾病或病症相关的至少一种症状的方法。 还提供了包含可用于各种治疗应用的目标单体双金属HCA化合物的组合物。