公开(公告)号：WO2023091929A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/079935

申请日：2022-11-16

Applicant: HEALTH RESEARCH, INC.

Inventor： ZHANG, Yuesheng ,  YANG, Lu ,  BHATTACHARYA, Arup ,  LI, Yun

IPC: A61K38/48 ,  A61P35/00 ,  A61K31/7115 ,  A61K31/737

Abstract: Provided are methods for treating cancer. The methods involve administering to an individual who has cancer a combination of peptidase D (PEPD), a sheddase inhibitor, a chemotherapeutic agent and a coagulation inhibitor.

公开(公告)号：WO2015031119A1

公开(公告)日：2015-03-05

申请号：PCT/US2014/051789

申请日：2014-08-20

Applicant: HEALTH RESEARCH, INC.

Inventor： LI, Yun ,  YANG, Lu ,  ZHANG, Yuesheng

IPC: A61K39/00

CPC classification number: A61K38/4813 ,  A61K39/00 ,  A61K45/06 ,  C07K2319/21 ,  C07K2319/30 ,  C12N9/485 ,  C12Y304/13009

Abstract: Provided are compositions and methods for prophylaxis and/or therapy of ErbB2-positive cancer. The compositions include pharmaceutical preparations that contain isolated or recombinant or modified peptidase D (PEPD) proteins. The methods include prophylaxis and/or therapy of ErbB2-positive cancer by administering a PEPD to an individual who has or is at risk for developing ErbB2- positive cancer.

Abstract translation: 提供了用于预防和/或治疗ErbB2阳性癌症的组合物和方法。 该组合物包括含有分离或重组或修饰的肽酶D（PEPD）蛋白的药物制剂。 所述方法包括通过对具有或有发展为ErbB2-阳性癌症风险的个体施用PEPD来预防和/或治疗ErbB2阳性癌症。

公开(公告)号：WO2006122214A2

公开(公告)日：2006-11-16

申请号：PCT/US2006/018147

申请日：2006-05-10

Applicant: HEALTH RESEARCH INC. ,  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  MOHLER, James, L. ,  TITUS, Mark ,  KOZYREVA, Olga ,  FORD, O'Harris,III ,  KAWINSKI, Elsbieta ,  LI, Yun

Inventor： MOHLER, James, L. ,  TITUS, Mark ,  KOZYREVA, Olga ,  FORD, O'Harris,III ,  KAWINSKI, Elsbieta ,  LI, Yun

IPC: C12Q1/68 ,  G01N33/574 ,  C12N9/02 ,  C12N15/861

CPC classification number: C12Q1/26 ,  C07K2319/21 ,  C07K2319/40 ,  C12N9/001 ,  C12N2799/022 ,  G01N33/57434

Abstract: The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIIL The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5 AIII by contacting SRD5 AIII with a test compound and measuring the activity of the enzyme. A reduced activity relative to a control indicates that the test compound is an inhibitor of SRD5AIII. A method is also provided for detecting androgen stimulated prostate cancer or recurrent prostate cancer in an individual. The method comprises obtaining a prostate biopsy from an individual and determining the level of expression of SRD5ADI gene or protein relative to a normal control. An increased expression of SRD5AIII relative to the control is indicative of androgen stimulated prostate cancer or recurrent prostate cancer.

Abstract translation: 本发明提供了一种称为SRD5AIIL的分离的新型类固醇5a-还原酶。该蛋白质具有37kDa的估计分子量，并且能够在约7.0的pH下将睾酮转化为二氢睾酮。 还提供了通过将SRD5AIII与测试化合物接触并测量酶的活性来鉴定SRD5AIII的抑制剂的方法。 相对于对照的降低的活性表明测试化合物是SRD5AIII的抑制剂。 还提供了用于检测个体中激素刺激的前列腺癌或复发性前列腺癌的方法。 该方法包括从个体获得前列腺活检，并确定SRD5ADI基因或蛋白质相对于正常对照的表达水平。 SRD5AIII相对于对照的增加的表达指示雄激素刺激的前列腺癌或复发性前列腺癌。

公开(公告)号：WO2016028956A1

公开(公告)日：2016-02-25

申请号：PCT/US2015/046000

申请日：2015-08-20

Applicant: HEALTH RESEARCH, INC.

Inventor： ZHANG, Yuesheng ,  YANG, Lu ,  LI, Yun ,  BHATTACHARYA, Arup

IPC: C12N9/48 ,  G01N33/573 ,  G01N33/68

CPC classification number: A61K38/4813 ,  A61K38/48 ,  A61K45/06 ,  A61P35/00 ,  C07K2319/55 ,  C12N9/485 ,  C12Y304/13009

Abstract: Provided are compositions and methods for prophylaxis and/or therapy of ErbBl - positive cancer. The compositions include pharmaceutical preparations that contain isolated or recombinant or modified peptidase D (PEPD) proteins. The methods include prophylaxis and/or therapy of ErbBl -positive cancer by administering a PEPD to an individual who has or is at risk for developing ErbB 1 -positive cancer.

Abstract translation: 提供了用于预防和/或治疗ErbB1阳性癌症的组合物和方法。 该组合物包括含有分离或重组或修饰的肽酶D（PEPD）蛋白的药物制剂。 所述方法包括通过对具有或具有发展为ErbB 1阳性癌症风险的个体施用PEPD来预防和/或治疗ErbB1-阳性癌症。

公开(公告)号：WO2017004385A1

公开(公告)日：2017-01-05

申请号：PCT/US2016/040423

申请日：2016-06-30

Applicant: HEALTH RESEARCH, INC.

Inventor： ZHANG, Yuesheng ,  YANG, Lu ,  LI, Yun ,  BHATTACHARYA, Arup

IPC: A61P25/28 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

CPC classification number: G01N33/6896 ,  G01N2333/4709 ,  G01N2400/40 ,  G01N2800/2821 ,  G01N2800/52 ,  G01N2800/7047

Abstract: A method for detecting circulating levels of beta amyloid peptides in an individual by administration of one or more inhibitors of an extracellular proteolytic pathway in blood and detection of the beta amyloid peptides in the blood or a fraction thereof. An example of an inhibitor is an anticoagulant. Levels of desired beta amyloid peptides such as Αβ1-40 and Αβ1-42 can be determined in the blood samples collected from the individuals.

Abstract translation: 通过在血液中施用一种或多种细胞外蛋白水解途径的抑制剂和检测血液中的β淀粉样蛋白肽或其一部分来检测个体中β淀粉样蛋白肽的循环水平的方法。 抑制剂的一个实例是抗凝血剂。 在从个体收集的血液样品中可以测定所需的β淀粉样肽如Aβ1-40和Aβ1-42的水平。

公开(公告)号：WO2021041912A1

公开(公告)日：2021-03-04

申请号：PCT/US2020/048547

申请日：2020-08-28

Applicant: HEALTH RESEARCH, INC.

Inventor： ZHANG, Yuesheng ,  LI, Yun ,  YANG, Lu

IPC: A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  A61P43/00

Abstract: Provided are methods for prophylaxis or therapy of cancer. The methods are directed to cancers that are characterized by expression of a mutant p53. The mutant p53 may be a loss of function p53 mutant, dominant negative p53 mutant, or a gain of function p53 mutant. The method comprises delivering to cancer cells an agent that can inhibit expression of prolidase (PEPD) or disrupts the association of mutant p53 with PEPD.

公开(公告)号：WO2011112919A2

公开(公告)日：2011-09-15

申请号：PCT/US2011/028076

申请日：2011-03-11

Applicant: HEALTH RESEARCH, INC ,  ZHANG, Yuesheng ,  BHATTACHARYA, Arup ,  TANG, Li ,  LI, Yun ,  PAONESSA, Joseph, D. ,  GENG, Feng ,  DING, Yi

Inventor： ZHANG, Yuesheng ,  BHATTACHARYA, Arup ,  TANG, Li ,  LI, Yun ,  PAONESSA, Joseph, D. ,  GENG, Feng ,  DING, Yi

CPC classification number: A61K31/26 ,  A61K36/31 ,  A61K2236/10

Abstract: Provided is a composition that contains a mixture of brocolli seed and mustard seed. Before mixning the brocolli seed with the mustard seed, the broccoli seed is subjected to baking and a pressurized heat treatment. The broccolli seed is baked at a temperature of at least 200 degrees Fahrenheit for at least 60 minutes, and is subjected to a pressurized heat treatment of at least 200 degrees Fahrenheit at a pressure of at least 10 pounds/square inch for at least 5 minutes. Also provided is a method for therapy and/or prophylaxis of bladder cancer in an individual The method entails administering orally to the individual a composition that contains an isothiocyanate (ITC) such that the administration inhibits the growth and/or recurrence of bladder cancer.

Abstract translation: 本发明提供含有芝麻籽和芥菜籽混合物的组合物。 在将芥菜种子与芥菜种子混合之前，将西兰花种子进行烘烤和加压热处理。 将青花菜种子在至少200华氏度的温度下烘烤至少60分钟，并在至少10磅/平方英寸的压力下进行至少200华氏度的加压热处理至少5分钟 。 还提供了治疗和/或预防个体中膀胱癌的方法。该方法需要向个体口服给予包含异硫氰酸酯（ITC）的组合物，使得该给药抑制膀胱癌的生长和/或复发。