公开(公告)号：WO2016016665A1

公开(公告)日：2016-02-04

申请号：PCT/GB2015/052233

申请日：2015-07-31

Applicant: HOVIONE INTERNATIONAL LTD ,  TURNER, Craig

Inventor： TEMTEM, Marcio ,  PEREIRA, Ruben ,  VICENTE, João ,  GASPER, Filipe ,  DUARTE, Iris

IPC: A61K9/14 ,  A61K9/16

CPC classification number: A61K9/146 ,  A61K9/10 ,  A61K9/1635 ,  A61K9/1694 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61K31/55

Abstract: The present invention discloses a method for producing amorphous solid dispersions in a nanoparticulate form, through solvent controlled co-precipitation, using microfluidization/microreaction technology to promote high energy mixing/interaction at a micro and/or molecular level between the streams involved in the process. Feed streams, solvent and anti-solvent, are fed to an intensifier pump at individually controlled rates and forced to interact to micro-and/or nano-scale within a microreactor. The present invention also discloses amorphous solid dispersions obtained by the method of the invention as well as pharmaceutical compositions containing the same.

Abstract translation: 本发明公开了一种通过溶剂控制共沉淀法制备纳米颗粒形式的无定形固体分散体的方法，使用微流化/微反应技术在微流程和/或分子水平上促进在该过程中涉及的流之间的高能量混合/相互作用 。 进料流，溶剂和反溶剂以单独控制的速率进料到增压泵，并在微反应器内强制与微量和/或纳米级相互作用。 本发明还公开了通过本发明的方法获得的无定形固体分散体以及含有它们的药物组合物。