公开(公告)号：WO2022093852A1

公开(公告)日：2022-05-05

申请号：PCT/US2021/056696

申请日：2021-10-26

申请人： IMARA INC. ,  VANDERBILT UNIVERSITY

发明人： BALLAL, Rahul Dilip ,  MACIEL, Thiago Trovati ,  GUPTA, Deepak ,  WANG, Thomas

IPC分类号： A61K31/4985 ,  A61K31/505 ,  A61P9/00 ,  C07D487/02 ,  C07D487/04

摘要： The present disclosure relates to PDE9 inhibitors, compositions comprising the PDE9 inhibitors, and methods of using the PDE9 inhibitors and compositions for treatment of cardiac failure.

公开(公告)号：WO2022036111A1

公开(公告)日：2022-02-17

申请号：PCT/US2021/045765

申请日：2021-08-12

申请人： IMARA INC.

发明人： BALLAL, Rahul Dilip

IPC分类号： A61P13/08 ,  A61P7/00 ,  C07D487/04

摘要： The present disclosure relates to methods for decreasing or increasing one or more biomarkers by administering PDE9 pharmaceutical compositions comprising 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one (Compound 1), or a pharmaceutically acceptable salt, solvate, or polymorph thereof, in a patient suffering from sickle cell disease (SCD) and/or sickle cell anemia (SCA).

公开(公告)号：WO2023014748A1

公开(公告)日：2023-02-09

申请号：PCT/US2022/039217

申请日：2022-08-02

申请人： IMARA INC.

发明人： BALLAL, Rahul Dilip

IPC分类号： A61K31/201 ,  A61K31/231 ,  A61K31/202 ,  A61K48/00

摘要： The present disclosure relates to methods of using nitrated fatty acids such as 10-nitro-9(E)-octadec-9-enoic acid (Compound 1), or a pharmaceutically acceptable salt or solvate thereof, in the treatment in sickle cell disease.