公开(公告)号：WO2023287896A1

公开(公告)日：2023-01-19

申请号：PCT/US2022/036986

申请日：2022-07-13

Applicant: INCYTE CORPORATION

Inventor： LI, Zhenwu ,  YU, Zhiyong ,  ROACH, Jeremy ,  HOANG, Gia ,  HU, Bin ,  LI, Gencheng ,  MCATEE, Rory ,  MUKAI, Ken ,  POLICARPO, Rocco ,  SUSICK, Robert ,  WANG, Xiaozhao ,  YAO, Wenqing

IPC: C07D471/04 ,  C07D519/00 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：WO2023091746A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/050558

申请日：2022-11-21

Applicant: INCYTE CORPORATION

Inventor： ARJONA, Alejandro Amador ,  ABDOLLAHI, Angela ,  FAVATA, Margaret ,  RIOS-DORIA, Jonathan ,  WANG, Hui ,  WEE, Susan ,  GAN, Pei ,  YANG, Jeffrey C. ,  LI, Yong ,  ZHAO, Le ,  HE, Chunhong ,  LAW, Chunyin Marshall ,  ZHU, Wenyu ,  WANG, Xiaozhao ,  YAO, Wenqing ,  CARLSEN, Peter ,  ZHANG, Fenglei ,  YE, Qinda ,  MCCAMMANT, Matthew ,  POLICARPO, Rocco ,  SHVARTSBART, Artem ,  ROACH, Jeremy ,  HOANG, Gia ,  HU, Bin ,  LI, Gencheng ,  SUSICK, Robert ,  POLAM, Padmaja ,  QI, Chao ,  SOKOLSKY, Alexander ,  YIN, Haolin ,  MIN, Chang

IPC: A61K31/4745 ,  A61K31/496 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  A61P35/00

Abstract: The present disclosure relates to methods of treating cancer by administering a compound, which is a Fibroblast Growth Factor Receptor (FGFR) inhibitor, in combination with a Kirsten rat sarcoma (KRAS) inhibitor.

公开(公告)号：WO2023034290A1

公开(公告)日：2023-03-09

申请号：PCT/US2022/042023

申请日：2022-08-30

Applicant: INCYTE CORPORATION

Inventor： LI, Gencheng ,  YIN, Haolin ,  QI, Chao ,  WANG, Xiaozhao ,  YAO, Wenqing ,  HU, Bin ,  CARLSEN, Peter

IPC: C07D471/14 ,  C07D519/00 ,  A61P35/00 ,  A61K31/4375

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：WO2023064857A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/078048

申请日：2022-10-13

Applicant: INCYTE CORPORATION

Inventor： YE, Qinda ,  MCCAMMANT, Matthew ,  POLICARPO, Rocco ,  SHVARTSBART, Artem ,  ZHU, Wenyu ,  ROACH, Jeremy ,  HOANG, Gia ,  HU, Bin ,  LI, Gencheng ,  SUSICK, Robert ,  POLAM, Padmaja ,  ZHANG, Fenglei ,  QI, Chao ,  WANG, Xiaozhao ,  YAO, Wenqing ,  SOKOLSKY, Alexander ,  YIN, Haolin ,  ZHAO, Le ,  CARLSEN, Peter

IPC: A61P35/00 ,  C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/4745

Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.