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公开(公告)号：WO1996040068A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008282
申请日：1996-05-30
Applicant: INHALE THERAPEUTIC SYSTEMS
IPC: A61K09/14
CPC classification number: A61K9/0075 , A61K9/1623 , Y10T428/2982
Abstract: The invention provides an agglomerate composition composed of units of aggregated fine particles and methods for its manufacture and use. The agglomerate composition units are composed of fine particles having a mean particle size in the range of 1 mu m to 5 mu m, and usually includes a medicament powder. The agglomerate units have a mean size in the range from 200 mu m to 500 mu m and have a friability index in the range from about 10 to 60.
Abstract translation: 本发明提供了由聚集的细颗粒单元组成的附聚物组合物及其制造和使用方法。 附聚物组合物单元由平均粒径为1μm〜5μm的细颗粒构成，通常包含药物粉末。 团聚体单元的平均尺寸为200μm〜500μm，脆性指数为10〜60左右。
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公开(公告)号：WO1996009085A1
公开(公告)日：1996-03-28
申请号：PCT/US1995011655
申请日：1995-09-15
Applicant: INHALE THERAPEUTIC SYSTEMS
Inventor： INHALE THERAPEUTIC SYSTEMS , SMITH, Adrian, E. , BURR, John, D. , ETTER, Jeffrey, W. , AXFORD, George, S. , LYONS, Shirley, W. , PLATZ, Robert, M.
IPC: A61M15/00
CPC classification number: A61M15/0045 , A61M15/0036 , A61M15/0041 , A61M15/0051 , A61M15/0055 , A61M2202/064 , A61M2205/0233 , A61M2205/073
Abstract: A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube (14) with a penetration in a receptacle (12) containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprises the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be formed in a continuous web placed in a cartridge (22). A separate piercing mechanism (26) may be provided.
Abstract translation: 用于雾化粉末状药物的方法包括将进料管（14）的粉末入口端与容纳有粉末的容器（12）中的穿透物接合。 粉末通过管向上拉，并分散在流过进料管的一部分的高压气流中。 设备包括安装在靠近用于一个或多个容器的保持器的基座外壳内的进料管，其可以形成在放置在盒（22）中的连续卷材中。 可以提供单独的穿孔机构（26）。
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