公开(公告)号：WO2022261498A1

公开(公告)日：2022-12-15

申请号：PCT/US2022/033106

申请日：2022-06-10

申请人： INTEGRATED PHARMA SERVICES, LLC

发明人： IZADJOO, Mina ,  KIM, Hosan ,  IZADJOO, Salman

IPC分类号： A61K35/76 ,  A61P17/10 ,  A61P31/04

摘要： Recombinantly-modified Cutibacterium acnes- specific bacteriophage, and recombinantly modified bacteriophage-derived endolysin enzyme are provided. Such compositions, alone or in combination with other antimicrobial agents or immunomodulators, may be used in pharmaceutical compositions, particularly pharmaceutical compositions to treat acne, promote wound healing, inhibit the growth of biofilms and to decrease the likelihood of, prevent or treat surgical related infections. The present invention is particularly directed to such formulations that are compounded for topical administration to a subject or used for application to medical devices. In particular, such pharmaceutical compositions may be compounded for topical administration to a subject, or compounded for application to a medical device.