公开(公告)号：WO2014143962A2

公开(公告)日：2014-09-18

申请号：PCT/US2014028167

申请日：2014-03-14

申请人： INTELOMED INC

发明人： BERKOW JAN K ,  BRUMFIELD ANNE M

IPC分类号： A61B5/00 ,  A61B5/024

CPC分类号： A61B5/026 ,  A61B5/4848 ,  A61B5/4869 ,  A61B5/4884 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7275

摘要： A computer-implemented method for characterizing circulatory blood volume and autoregulatory compensatory mechanisms to maintain circulatory blood volume is disclosed. A biological signal that emulates the arterial pulse wave is collected from a sensor. Three derived parameters are extrapolated from the biological signal. The first parameter, circulatory stress, reflects of the changes of the heart rate frequency. The second, circulatory blood volume, reflects the changes in the frequency strength of the heart rate frequency. The third, Pulse Volume Alteration (PVA) Index is a ratio of the sum of the strengths of the heart rate frequency harmonics to the strength of the heart rate frequency of the unprocessed biological signal. Each parameter is compared to a threshold value and assessed to determine an adequacy of circulatory blood volume and an appropriateness of the autoregulatory mechanisms used to maintain circulatory blood volume adequacy.

摘要翻译： 公开了一种用于表征循环血液体积的计算机实现方法和用于维持循环血液体积的自动调节补偿机制。 从传感器收集模拟动脉脉搏波的生物信号。 从生物信号外推三个派生参数。 第一个参数是循环应激反映心率变化的频率。 第二，循环血量反映了心率频率频率变化的变化。 第三，脉搏体积改变（PVA）指数是心率频率谐波的强度之和与未处理的生物信号的心率频率的强度的比值。 将每个参数与阈值进行比较，并进行评估以确定循环血液体积的充足性以及用于维持循环血容量充足性的自动调节机制的适当性。

公开(公告)号：WO2014143962A3

公开(公告)日：2015-04-09

申请号：PCT/US2014028167

申请日：2014-03-14

申请人： INTELOMED INC

发明人： BERKOW JAN K ,  BRUMFIELD ANNE M

IPC分类号： A61B8/14

CPC分类号： A61B5/026 ,  A61B5/4848 ,  A61B5/4869 ,  A61B5/4884 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7275

摘要： A computer-implemented method for characterizing circulatory blood volume and autoregulatory compensatory mechanisms to maintain circulatory blood volume is disclosed. A biological signal that emulates the arterial pulse wave is collected from a sensor. Three derived parameters are extrapolated from the biological signal. The first parameter, circulatory stress, reflects of the changes of the heart rate frequency. The second, circulatory blood volume, reflects the changes in the frequency strength of the heart rate frequency. The third, Pulse Volume Alteration (PVA) Index is a ratio of the sum of the strengths of the heart rate frequency harmonics to the strength of the heart rate frequency of the unprocessed biological signal. Each parameter is compared to a threshold value and assessed to determine an adequacy of circulatory blood volume and an appropriateness of the autoregulatory mechanisms used to maintain circulatory blood volume adequacy.

摘要翻译： 公开了一种用于表征循环血液体积的计算机实现方法和用于维持循环血液体积的自动调节补偿机制。 从传感器收集模拟动脉脉搏波的生物信号。 从生物信号外推三个派生参数。 第一个参数是循环应激反映心率变化的频率。 第二，循环血量反映了心率频率频率变化的变化。 第三，脉搏体积改变（PVA）指数是心率频率谐波的强度之和与未处理的生物信号的心率频率的强度的比值。 将每个参数与阈值进行比较，并进行评估以确定循环血液体积的充足性以及用于维持循环血容量充足性的自动调节机制的适当性。