公开(公告)号：WO2007031572A1

公开(公告)日：2007-03-22

申请号：PCT/EP2006/066401

申请日：2006-09-15

Applicant: INTERVET INTERNATIONAL B.V. ,  BREMONT, Michel ,  LE BERRE, Monique ,  MORIETTE, Coralie ,  VILLOING, Stephane

Inventor： BREMONT, Michel ,  LE BERRE, Monique ,  MORIETTE, Coralie ,  VILLOING, Stephane

IPC: C07K14/18 ,  A61K39/12

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K2039/552 ,  A61K2039/55566 ,  C07K2319/00 ,  C07K2319/21 ,  C12N2770/36122 ,  C12N2770/36134

Abstract: The present invention relates to veterinary immunology, namely to the immunological response of fish to a virus. More specifically, the invention provides an epitope of salmonid alphaviruses which epitope is capable of inducing a virus neutralising immune response. In particular the invention relates to a polypeptide comprising a certain amino acid sequence, a protein comprising such polypeptide, to a carrier comprising such protein, and to a method of producing antibodies. Further the invention relates to a nucleic acid encoding such polypeptide or such protein, and to a carrier comprising such a nucleic acid. Also, the invention relates to a vaccine and a diagnostic kit comprising such a polypeptide, protein, carrier, or nucleic acid.

Abstract translation: 本发明涉及兽医免疫学，即针对病毒的免疫应答。 更具体地，本发明提供了表位能够诱导病毒中和免疫应答的鲑鱼甲病毒表位。 特别地，本发明涉及包含某种氨基酸序列的多肽，包含这种多肽的蛋白质，涉及包含这种蛋白质的载体，以及产生抗体的方法。 此外，本发明涉及编码这种多肽或这种蛋白质的核酸，以及包含这种核酸的载体。 此外，本发明涉及包含这种多肽，蛋白质，载体或核酸的疫苗和诊断试剂盒。

公开(公告)号：WO2012089749A1

公开(公告)日：2012-07-05

申请号：PCT/EP2011/074121

申请日：2011-12-28

Applicant: INTERVET INTERNATIONAL B.V. ,  VILLOING, Stephane

Inventor： VILLOING, Stephane

IPC: C07K14/18 ,  A61K39/12

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/295 ,  A61K2039/552 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2770/36151

Abstract: The present invention relates to Salmonid alphavirus E2 -protein expressed in a bacterial expression system, its use in medicine, vaccines comprising such protein, methods for the preparation of such proteins and methods for the preparation of vaccines comprising such proteins.

Abstract translation: 本发明涉及在细菌表达系统中表达的鲑鱼病毒E2-蛋白质，其在医药中的应用，包含这种蛋白质的疫苗，用于制备这种蛋白质的方法以及制备包含这种蛋白质的疫苗的方法。

公开(公告)号：WO2003035680A1

公开(公告)日：2003-05-01

申请号：PCT/EP2002/011552

申请日：2002-10-16

Applicant: AKZO NOBEL N.V. ,  VILLOING, Stephane ,  BIERING, Erik

Inventor： VILLOING, Stephane ,  BIERING, Erik

IPC: C07K14/11

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/02 ,  C12N2760/16022 ,  C12N2760/16034

Abstract: The present invention relates to a nucleic acid sequence encoding an 48kD Infectious Salmon Anaemia virus protein and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising this nucleic acid sequence. The invention also relates to a protein encoded by this sequence as well as to vaccines comprising this protein or antibodies against his protein. Moreover, the invention relates to the use of said nucleic acid sequence, protein or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising the nucleic acid, protein or antibodies against the protein.

Abstract translation: 本发明涉及编码48kD感染性三文鱼贫血病毒蛋白的核酸序列和涉及包含该核酸序列的DNA片段，重组DNA分子，活重组载体和宿主细胞。 本发明还涉及由该序列编码的蛋白质以及包含该蛋白质的疫苗或针对其蛋白质的抗体。 此外，本发明涉及用于诊断或疫苗接种目的的所述核酸序列，蛋白质或抗体的用途。 最后，本发明涉及包含针对蛋白质的核酸，蛋白质或抗体的诊断试剂盒。

公开(公告)号：WO2019110664A1

公开(公告)日：2019-06-13

申请号：PCT/EP2018/083656

申请日：2018-12-05

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： VILLOING, Stephane ,  HODNELAND, Kjartan ,  FROST, Petter

IPC: A61K39/12 ,  A61K39/15 ,  C07K14/14 ,  A61P31/14

CPC classification number: A61K39/12 ,  A61K39/15 ,  A61K2039/552 ,  A61P31/14 ,  C07K14/14

Abstract: The present invention is directed to a treatment method in fish against heart and skeletal muscle inflammation caused by Piscine orthoreovirus (PRV) by using PRV non-structural protein. The invention is further directed to vectors comprising a promoter sequence and a DNA-encoding sequence that encodes for a PRV non-structural protein and to vaccine compositions comprising such vectors.

公开(公告)号：WO2021123099A1

公开(公告)日：2021-06-24

申请号：PCT/EP2020/086935

申请日：2020-12-18

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： VILLOING, Stephane ,  LEININGER, Sven ,  HODNELAND, Kjartan ,  KOUMANS, Joseph

IPC: C07K14/11 ,  C12N2760/16021 ,  C12N2760/16034 ,  C12N2760/16051 ,  C12N2760/16064 ,  C12N7/00

Abstract: The present invention is directed to a reassorted ISA virus comprising Genome segments 1-8 wherein at least one genome segment is from Genotype I and at least one genome segment is from genotype II, wherein genome segment 6 is of Genotype II. The reassorted ISA virus was found to grow well in suspension culture. The present invention is also directed to method to make the reassorted virus as well as vaccination methods using the reassorted ISA virus and to vaccine compositions comprising the reassorted ISA virus.

公开(公告)号：WO2021122507A1

公开(公告)日：2021-06-24

申请号：PCT/EP2020/086086

申请日：2020-12-15

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： BIJLSMA, Johanna, Jacoba, Elisabeth ,  LEININGER, Sven ,  VILLOING, Stephane

IPC: A61K39/12 ,  A61K39/15 ,  A61P31/14 ,  C07K14/14 ,  A61K2039/552

Abstract: The invention derives from the discovery that the immunogenicity of piscine orthoreovirus (PRV) can be significantly increased by inactivating the virus in a way different from the prior art: by incubation with an aziridine the vaccine potency against challenge infection by cohabitation is much improved over prior art approaches. This allowed the development of an effective inactivated vaccine against infection and disease caused by PRV.