公开(公告)号：WO2016179518A3

公开(公告)日：2016-11-10

申请号：PCT/US2016/031260

申请日：2016-05-06

Applicant: JANSSEN BIOTECH, INC.

Inventor： ANDERSON, Glenn ,  CARDOSO, Rosa ,  DIEM, Michael ,  GAUDET, Francois ,  GOLDBERG, Shalom ,  HARMAN, Benjamin C. ,  HYUN, Linus ,  JACOBS, Steven ,  KLEIN, Donna ,  LI, Yingzhe ,  LUO, Jinquan ,  MCDAID, Ronan ,  NEMETH-SEAY, Jennifer ,  O'NEIL, Karyn ,  POMERANTZ, Steven C. ,  CHANDRA RAO, Galla ,  SPINKA-DOMS, Tracy ,  TEPLYAKOV, Alexey ,  WU, Sheng-Jiun ,  MOONEY, Jill ,  LUISTRO, Leopoldo

IPC: A61K39/395 ,  A61P35/00 ,  C07K16/00 ,  C07K16/28

Abstract: Provided herein are isolated CD3 x PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3 x PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.

公开(公告)号：WO2016179518A2

公开(公告)日：2016-11-10

申请号：PCT/US2016/031260

申请日：2016-05-06

Applicant: JANSSEN BIOTECH, INC.

Inventor： ANDERSON, Glenn ,  CARDOSO, Rosa ,  DIEM, Michael ,  GAUDET, Francois ,  GOLDBERG, Shalom ,  HARMAN, Benjamin C. ,  HYUN, Linus ,  JACOBS, Steven ,  KLEIN, Donna ,  LI, Yingzhe ,  LUO, Jinquan ,  MCDAID, Ronan ,  NEMETH-SEAY, Jennifer ,  O'NEIL, Karyn ,  POMERANTZ, Steven C. ,  CHANDRA RAO, Galla ,  SPINKA-DOMS, Tracy ,  TEPLYAKOV, Alexey ,  WU, Sheng-Jiun ,  MOONEY, Jill ,  LUISTRO, Leopoldo

IPC: A61K39/395 ,  A61P16/28 ,  C07K16/28

CPC classification number: C07K16/2809 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6869 ,  A61K49/0045 ,  A61K49/0058 ,  A61K2039/505 ,  C07K14/78 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2318/20 ,  C07K2319/30 ,  C12Y304/17021

Abstract: Provided herein are isolated CD3 x PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3 x PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.

Abstract translation: 本文提供了分离的CD3x PSMA-双特异性抗原结合分子或其双特异性抗原结合片段，其中FN3结构域特异性结合人前列腺特异性膜抗原（PSMA）和第二抗原结合位点免疫特异性地 结合CD3。 还描述了能够编码所提供的融合蛋白的融合蛋白和相关多核苷酸，以及表达提供的融合蛋白的细胞。 此外，描述了使用提供的分离的CD3 x PSMA双特异性抗原结合分子或其双特异性抗原结合片段的方法。