公开(公告)号：WO2019154931A1

公开(公告)日：2019-08-15

申请号：PCT/EP2019/053047

申请日：2019-02-07

Applicant: JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG ,  ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

Inventor： WOLLBORN, Jakob ,  GOEBEL, Ulrich ,  SCHICK, Martin ,  HERRMANN, Cornelius ,  WUNDER, Christian ,  MEINEL, Lorenz ,  STEIGER, Christoph ,  MERGET, Benjamin

IPC: A61M1/36 ,  A61K31/28 ,  A61K31/69

Abstract: The present invention relates to a method for combined administration of carbon monoxide (CO) to an ex-vivo fluid and monitoring of the carbon monoxide administration, said method comprising: (i) generating CO by reacting a CO releasing molecule (CORM) with a release triggering molecule; (ii) administering CO to an ex-vivo fluid by contacting the ex-vivo fluid with the CO generated in step (i) via a gas-permeable membrane; (iii) analyzing carbon monoxide and/or a carbon monoxide marker after administering in step (ii) CO to the ex-vivo fluid by complementary monitoring techniques; (iv) adjusting the CO administration based on the analysis of the carbon monoxide or the carbon monoxide marker carried out in step (iii), if necessary. It furthermore relates to an extracorporeal circuit system for use in the method of the invention.

公开(公告)号：WO2016110517A1

公开(公告)日：2016-07-14

申请号：PCT/EP2016/050146

申请日：2016-01-07

Applicant: JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG

Inventor： MEINEL, Lorenz ,  STEIGER, Christoph ,  WUNDER, Christian

IPC: A01N1/02 ,  A61L2/20 ,  A61L2/26 ,  A61K33/00

CPC classification number: A01N1/0226 ,  A01N1/0236 ,  A01N1/0242 ,  A61K33/00

Abstract: The present invention relates to a gas delivery device comprising a gas releasing molecule and a gas permeable membrane. The invention also relates to the use of the gas delivery device for delivery of gas to an extracorporeal transplant, extracorporeal cells, a brain-dead transplant donor or foodstuff and in therapy. The invention further relates to the use of a gas permeable and liquid and solid impermeable membrane to separate a gas releasing molecule and its non-gaseous degradation products from an extracorporeal transplant, extracorporeal cells, a brain-dead transplant donor or foodstuff.

Abstract translation: 本发明涉及一种包括气体释放分子和气体渗透膜的气体输送装置。 本发明还涉及用于将气体输送到体外移植物，体外细胞，脑死亡移植供体或食物以及治疗中的气体输送装置的用途。 本发明还涉及使用气体可渗透且液体和固体不可渗透的膜将气体释放分子及其非气态降解产物与体外移植物，体外细胞，脑死亡移植供体或食物分离。