公开(公告)号：WO2017203250A1

公开(公告)日：2017-11-30

申请号：PCT/GB2017/051461

申请日：2017-05-24

Applicant: KING'S COLLEGE LONDON

Inventor： NIEDERER, Steven ,  CORRADO, Cesare

IPC: A61B5/0452 ,  G06F19/00 ,  A61B5/00 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0464

Abstract: Embodiments of the invention provide a method and apparatus that allow for a personalised heart tissue model to be generated, that models heart tissue electrophysiology behaviour at a personalised level, based upon activation measurements of an individual subject's heart in response to a number of predefined pacing protocols. The activation measurements are collected using a catheter placed onto the subject's heart, which is then paced via the catheter in accordance with the pacing protocols, and activation times of the heart tissue recorded. The activation measurements are used to generate a personalised tissue model, for example, by parameter matching the activation measurements with a large number of predefined sets of activation measurements, to determine the best-fit set; the best-fit set is then used as a personalised heart tissue model in a two or three -dimensional simulation of heart tissue activation in response to simulated stimulation.

Abstract translation: 本发明的实施例提供了一种方法和装置，其允许生成个性化心脏组织模型，该个性化心脏组织模型基于个体对象的心脏的激活测量来在个性化水平上对心脏组织电生理行为进行建模 响应多个预定义的步调协议。 使用放置在受试者心脏上的导管收集激活测量结果，然后根据起搏方案经由导管起搏并记录心脏组织的激活时间。 激活测量被用于生成个性化组织模型，例如，通过将激活测量与大量预定义的激活测量集相匹配来确定最佳拟合集; 然后将最适合的组合用作个体心脏组织模型，以模拟刺激对心脏组织激活的二维或三维模拟。

公开(公告)号：WO2022162329A1

公开(公告)日：2022-08-04

申请号：PCT/GB2021/050182

申请日：2021-01-26

Applicant: KING'S COLLEGE LONDON

Inventor： CORRADO, Cesare ,  NIEDERER, Steven

IPC: A61B5/287 ,  A61B5/35 ,  A61B5/00 ,  G16H50/50

Abstract: The present disclosure provides a system and a method for characterising heart tissue properties, in particular characterising heart tissue properties associated with regions that tether arrhythmia, for example, re-entrant activation patterns relating to AF.