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1.发明申请CONTINUOUS COUNTERCURRENT FLUIDIZED MOVING BED (FMB) AND/OR EXPANDED MOVING BED (EMB) 审中-公开连续逆流流动移动床（FMB）和/或扩展移动床（EMB）
公开(公告)号：WO2010103541A3
公开(公告)日：2010-11-18
申请号：PCT/IN2010000133
申请日：2010-03-09
发明人： LALI ARVIND MALLINATH , KALE SANDEEP BHASKAR , PAKHALE VINOD DINKAR , THAKARE YOGESHWAR NARAYANRAO
摘要： The composite continuous countercurrent fluidized moving bed (FMB) and/or expanded moving bed (EMB) for carrying out processes such as recovery, purification or reaction of single or multiple component/s of interest, by contacting liquid phase containing the said component/s with the solid adsorbent in continuous countercurrent mode. In this composite fluidized moving bed and/or expanded moving bed system the net movement of the solids is against the liquid flowing in upward direction through the stages/columns, and sedimenting solids from the one stage/column are continuously fed to the top of the another stage/column placed below or alongside of previous stage/column, and also operating in fluidized/expanded bed mode, wherein its countercurrent contact with up flowing liquid is carried out. The system described herein consists of number of stages/column as per requirement of the process. The sedimenting adsorbent solids from the last fluidized bed or expanded bed stage/column are taken out continuously and fed back to the top of the first stage/column, through a feed hopper to which the adsorbent solids are transported by means of pump or liquid solid ejector, or any other suitable device. The feed hopper is suitably designed and operated, so as deliver solid adsorbents to the top of the first stage/column continuously in a controlled manner. The flow of solid adsorbent through the said solid downcomer tube/s is controlled using valves appropriate to afford control over the downward adsorbent flow. The FMB/EMB system can be used in processes for continuous recovery, purifications or reactions of various products.
摘要翻译： 复合连续逆流流化床（FMB）和/或膨胀移动床（EMB），用于通过使含有所述组分的液相接触来进行诸如单个或多个感兴趣组分的回收，纯化或反应的过程 固体吸附剂处于连续逆流模式。 在该复合流化移动床和/或膨胀移动床系统中，固体的净运动抵抗通过级/柱向上流动的液体，并且来自一级/柱的沉降固体连续地进料到 位于前一级/柱下方或旁边的另一级/柱，并且还以流化床/膨胀床模式操作，其中与上流液体的逆流接触被执行。 本文描述的系统包括根据过程要求的阶段数/列数。 来自最后流化床或膨胀床阶段/塔的沉积吸附剂固体被连续地取出并通过进料斗通过泵或液体固体输送到吸入剂固体上的第一阶段/塔的顶部 喷射器或任何其他合适的装置。 进料斗适当地设计和操作，以便以受控的方式连续地将固体吸附剂输送到第一级/塔的顶部。 通过所述固体降液管的固体吸附剂的流动是通过适当的控制向下的吸附剂流动的阀来控制的。 FMB / EMB系统可用于各种产品的连续回收，纯化或反应过程。
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2.发明申请CONTINUOUS COUNTERCURRENT FLUIDIZED MOVING BED (FMB) AND/OR EXPANDED MOVING BED (EMB) 审中-公开连续逆流流动移动床（FMB）和/或扩展移动床（EMB）
公开(公告)号：WO2010103541A4
公开(公告)日：2011-01-20
申请号：PCT/IN2010000133
申请日：2010-03-09
发明人： LALI ARVIND MALLINATH , KALE SANDEEP BHASKAR , PAKHALE VINOD DINKAR , THAKARE YOGESHWAR NARAYANRAO
摘要： The composite continuous countercurrent fluidized moving bed (FMB) and/or expanded moving bed (EMB) for carrying out processes such as recovery, purification or reaction of single or multiple component/s of interest, by contacting liquid phase containing the said component/s with the solid adsorbent in continuous countercurrent mode. In this composite fluidized moving bed and/or expanded moving bed system the net movement of the solids is against the liquid flowing in upward direction through the stages/columns, and sedimenting solids from the one stage/column are continuously fed to the top of the another stage/column placed below or alongside of previous stage/column, and also operating in fluidized/expanded bed mode, wherein its countercurrent contact with up flowing liquid is carried out. The system described herein consists of number of stages/column as per requirement of the process. The sedimenting adsorbent solids from the last fluidized bed or expanded bed stage/column are taken out continuously and fed back to the top of the first stage/column, through a feed hopper to which the adsorbent solids are transported by means of pump or liquid solid ejector, or any other suitable device. The feed hopper is suitably designed and operated, so as deliver solid adsorbents to the top of the first stage/column continuously in a controlled manner. The flow of solid adsorbent through the said solid downcomer tube/s is controlled using valves appropriate to afford control over the downward adsorbent flow. The FMB/EMB system can be used in processes for continuous recovery, purifications or reactions of various products.
摘要翻译： 复合连续逆流流化床（FMB）和/或膨胀移动床（EMB），用于通过使含有所述组分的液相接触来进行诸如单个或多个感兴趣组分的回收，纯化或反应的过程 固体吸附剂处于连续逆流模式。 在该复合流化移动床和/或膨胀移动床系统中，固体的净运动抵抗通过级/柱向上流动的液体，并且来自一级/柱的沉降固体连续地进料到 位于前一级/柱下方或旁边的另一级/柱，并且还以流化床/膨胀床模式操作，其中与上流液体的逆流接触被执行。 本文描述的系统包括根据过程要求的阶段数/列数。 来自最后流化床或膨胀床阶段/塔的沉积吸附剂固体被连续地取出并通过进料斗通过泵或液体固体输送到吸入剂固体上的第一阶段/塔的顶部 喷射器或任何其他合适的装置。 进料斗适当地设计和操作，以便以受控的方式连续地将固体吸附剂输送到第一级/塔的顶部。 通过所述固体降液管的固体吸附剂的流动是通过适当的控制向下的吸附剂流动的阀来控制的。 FMB / EMB系统可用于各种产品的连续回收，纯化或反应过程。
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公开(公告)号：WO2007120263A3
公开(公告)日：2007-12-21
申请号：PCT/US2006060767
申请日：2006-11-10
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , KATKAM SRINIVAS , KOMATI SATYANARAYANA , GUDIPATI SRINIVASULU , PITTA JAYAPRAKASH , CHALLA NAGESWARA RAO , BUCCHIKONDLA RAVINDER , MALLINA SRINIVASA RAO , GOLDWYN ADOLF CEASER , KHARKAR MANOJ RAMESH , NARSAPUR SHARAT PANDURANG , MADDULA SRINIVASULA REDDY , KASULA RAMAMURTHY , LALI ARVIND MALLINATH , KALE SANDEEP BHASKAR , BHORI ABIJAR JOYEBBHAI
发明人： KATKAM SRINIVAS , KOMATI SATYANARAYANA , GUDIPATI SRINIVASULU , PITTA JAYAPRAKASH , CHALLA NAGESWARA RAO , BUCCHIKONDLA RAVINDER , MALLINA SRINIVASA RAO , GOLDWYN ADOLF CEASER , KHARKAR MANOJ RAMESH , NARSAPUR SHARAT PANDURANG , MADDULA SRINIVASULA REDDY , KASULA RAMAMURTHY , LALI ARVIND MALLINATH , KALE SANDEEP BHASKAR , BHORI ABIJAR JOYEBBHAI
IPC分类号： C07D221/18
CPC分类号： C07D221/18
摘要： Dutasteride having low concentrations of impurities, such as dihydrodutasteride and desmethyldutasteride, and processes for purifying dutasteride.
摘要翻译： 具有低浓度杂质的度他雄胺，例如二氢他雄胺和去甲基去量他雄胺，以及纯化度他雄胺的方法。
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4.发明申请A PROCESS FOR PURIFICATION OF IMMUNOGLOBULINS USING A PSEUDOBIOAFFINITY ADSORBENT 审中-公开利用假性吸附剂吸附纯化免疫球蛋白的方法
公开(公告)号：WO2009007993A3
公开(公告)日：2009-03-19
申请号：PCT/IN2008000254
申请日：2008-04-23
IPC分类号： C07K16/06
CPC分类号： C07K16/065 , Y10T428/249991 , Y10T428/249992
摘要： The present invention relates to the development of pseudobioaffinity adsorbent and process for purification of immunoglobulin G from immunoglobulin containing solutions such as but not limited to plasma, serum, cell culture supernatant, ascites fluids. The adsorbent consists of a solid support and ligand. The ligand may be attached to the matrix or be part of matrix. The ligand is selected from a group of hydrophobic amino acids such as alanine, valine, leucine, isoleucine, proline, phenylalanine, tryptophan and tyrosine and the support material being preferably a synthetic hydrophilic polymer of methacrylate or acrylate species, or any of its derivatives. The adsorbent is cheap and stable to harsh conditions such as 1.0 M NaOH used during regeneration of adsorbents. Moreover there is no problem of toxic leachables typically associated with biological ligands. The nature of the adsorbent also allows high flow rate operations at relatively low pressures. The process includes adjusting the pH and conductivity of the feed solution and the use of ionic salts and additives such as polyols or alcohols for eluting the bound IgG.
摘要翻译： 本发明涉及拟免疫吸附剂的开发以及用于从含免疫球蛋白的溶液（例如但不限于血浆，血清，细胞培养物上清液，腹水）中纯化免疫球蛋白G的方法。 吸附剂由固体载体和配体组成。 配体可以连接到基质上或者是基质的一部分。 配体选自疏水氨基酸如丙氨酸，缬氨酸，亮氨酸，异亮氨酸，脯氨酸，苯丙氨酸，色氨酸和酪氨酸，并且载体材料优选为甲基丙烯酸酯或丙烯酸酯物种的合成亲水聚合物或其任何衍生物。 该吸附剂便宜且对苛刻条件稳定，例如吸附剂再生期间使用的1.0M NaOH。 此外，通常与生物配体相关的毒性可浸出物没有问题。 吸附剂的性质也允许在相对低的压力下进行高流速操作。 该方法包括调节进料溶液的pH和电导率，并使用离子盐和添加剂如多元醇或醇来洗脱结合的IgG。
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公开(公告)号：WO2009007993A2
公开(公告)日：2009-01-15
申请号：PCT/IN2008000254
申请日：2008-04-23
CPC分类号： C07K16/065 , Y10T428/249991 , Y10T428/249992
摘要： The present invention relates to the development of pseudobioaffinity adsorbent and process for purification of immunoglobulin G from immunoglobulin containing solutions such as but not limited to plasma, serum, cell culture supernatant, ascites fluids. The adsorbent consists of a solid support and ligand. The ligand may be attached to the matrix or be part of matrix. The ligand is selected from a group of hydrophobic amino acids such as alanine, valine, leucine, isoleucine, proline, phenylalanine, tryptophan and tyrosine and the support material being preferably a synthetic hydrophilic polymer of methacrylate or acrylate species, or any of its derivatives. The adsorbent is cheap and stable to harsh conditions such as 1.0 M NaOH used during regeneration of adsorbents. Moreover there is no problem of toxic leachables typically associated with biological ligands. The nature of the adsorbent also allows high flow rate operations at relatively low pressures. The process includes adjusting the pH and conductivity of the feed solution and the use of ionic salts and additives such as polyols or alcohols for eluting the bound IgG.
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