公开(公告)号：WO2013162742A1

公开(公告)日：2013-10-31

申请号：PCT/US2013/031284

申请日：2013-03-14

Applicant: LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER

Inventor： SPELLBERG, Brad, J. ,  LIN, Lin

IPC: A01N37/18 ,  A61K38/00 ,  A61P31/04 ,  A61K38/17

CPC classification number: A61K38/1709 ,  A61K38/40 ,  Y02A50/401 ,  Y02A50/469 ,  Y02A50/481 ,  Y02A50/483

Abstract: The invention provides a method of killing an infectious microbe by administering an effective amount of transferrin to an individual having a microbial infection, wherein the transferrin has microbicidal activity, thereby reducing survival of the infectious microbe in the individual. The invention also provides a method of prophylactically treating an individual to decrease the likelihood of contracting a microbial infection, comprising administering an effective amount of transferrin to an individual, wherein the transferrin has microbicidal activity, thereby decreasing the likelihood that the individual will contract a microbial infection. The invention still further provides a method of treating septicemia by administering an effective amount of transferrin to an individual in need thereof, thereby treating the individual.

Abstract translation: 本发明提供了通过向具有微生物感染的个体施用有效量的转铁蛋白来杀死感染性微生物的方法，其中转铁蛋白具有杀微生物活性，从而降低个体感染性微生物的存活。 本发明还提供一种预防性治疗个体以减少微生物感染的可能性的方法，包括向个体施用有效量的转铁蛋白，其中所述转铁蛋白具有杀微生物活性，从而降低个体将收缩微生物的可能性 感染。 本发明还提供了通过向有需要的个体施用有效量的转铁蛋白来治疗败血症的方法，从而治疗个体。

公开(公告)号：WO2013112696A1

公开(公告)日：2013-08-01

申请号：PCT/US2013/022908

申请日：2013-01-24

Applicant: LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER

Inventor： SPELLBERG, Brad, J. ,  LIN, Lin

IPC: A61P31/04

CPC classification number: C12N9/86 ,  A61K2039/505 ,  C07K16/1203 ,  C07K16/40 ,  C12Y305/02006

Abstract: The present invention provides vaccine and pharmaceutical compositions for treating or preventing bacterial inventions. The vaccine compositions of the invention include a carbapenemase such as a serine carbapenemase, a metallo-β-lactamase or an immunogenic fragment thereof. The pharmaceutical compositions include an anti-carbapenemase antibody or fragment thereof. Also provided are methods for treating and preventing a bacterial infection using the vaccine and pharmaceutical compositions of the invention. The invention further provides antibody conjugates that include an antibody or fragment thereof conjugated to a siderophore or an analog thereof.

Abstract translation: 本发明提供用于治疗或预防细菌发明的疫苗和药物组合物。 本发明的疫苗组合物包括碳青霉烯酶如丝氨酸碳青霉烯酶，金属β-内酰胺酶或其免疫原性片段。 药物组合物包括抗碳青霉烯酶抗体或其片段。 还提供了使用本发明的疫苗和药物组合物治疗和预防细菌感染的方法。 本发明还提供了抗体缀合物，其包括与铁载体或其类似物缀合的抗体或其片段。

公开(公告)号：WO2012158529A2

公开(公告)日：2012-11-22

申请号：PCT/US2012/037550

申请日：2012-05-11

Applicant: LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER ,  SPELLBERG, Brad, J. ,  LIN, Lin ,  IBRAHIM, Ashraf, S. ,  LUO, Guanpingsheng

Inventor： SPELLBERG, Brad, J. ,  LIN, Lin ,  IBRAHIM, Ashraf, S. ,  LUO, Guanpingsheng

IPC: A61K39/02 ,  C07K14/21 ,  C07K7/08 ,  C07K7/06 ,  C07K5/08 ,  C12N15/31 ,  C12N15/63 ,  C07K16/12 ,  A61K39/395 ,  A61P31/04 ,  A61P37/04

CPC classification number: C07K14/22 ,  A61K39/02 ,  A61K39/104 ,  A61K2039/55505 ,  C07K14/212 ,  C07K16/1203 ,  C07K16/1217 ,  C07K2317/34

Abstract: The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization against A. baumannii infection. The invention also provides antibodies and antigen-binding parts thereof that specifically bind to OmpA, and related methods of passive immunization against A. baumannii infection. The compositions and methods of the invention are useful for preventing or treating A. baumannii infections, including those caused by strains resistant to carbapenems and all other antibiotics except colistin or tigecycline, also referred to as extreme drug resistant (XDR) A. baumannii infections, and those resistant to every FDA approved antibiotic, also referred to as pan-drug resistant (PDR) A. baumannii infections.

Abstract translation: 本发明提供包含OmpA或其抗原性片段的疫苗组合物，以及针对鲍曼不动杆菌感染的主动免疫的相关方法。 本发明还提供了特异性结合OmpA的抗体及其抗原结合部分，以及针对鲍氏不动杆菌感染的相关的被动免疫方法。 本发明的组合物和方法可用于预防或治疗鲍曼不动杆菌感染，包括由对碳青霉烯类耐受的菌株和除粘菌素或替加环素之外的所有其它抗生素引起的鲍曼不动杆菌感染，也被称为极耐药（XDR）A.鲍曼不动杆菌感染， 而那些对每一个FDA批准的抗生素都有抗药性，也被称为泛耐药（PDR）A.鲍曼不动杆菌感染。