公开(公告)号：WO2018102508A1

公开(公告)日：2018-06-07

申请号：PCT/US2017/063871

申请日：2017-11-30

Applicant: LUBRIZOL ADVANCED MATERIALS, INC.

Inventor： VAN DEN NEST, Wim ,  RODRIGUEZ BIELSA, Katalina ,  LAPORTA, Olga ,  GARCIA SANZ, Nuria ,  ALMIÑANA DOMÈNECH, Nuria

IPC: C07K14/705

Abstract: A compound of formula (I) R 1 -W m -X n -AA 1 -AA 2 -AA 3 -AA 4 -AA 5 -AA 6 -(AA 7 ) a -(AA 8 ) b -Y p -Z q -R 2 effective in maintaining and/or improving the physical and immunological barrier functions of the skin and useful in the treatment and/or care of the skin, hair, nails and/or mucous membranes.

公开(公告)号：WO2017100421A1

公开(公告)日：2017-06-15

申请号：PCT/US2016/065568

申请日：2016-12-08

Applicant: LUBRIZOL ADVANCED MATERIALS, INC.

Inventor： ALMINANA DOMENECH, Nuria ,  VAN DEN NEST, Wim ,  DEL CARMEN LIDON, Maria ,  FERRER MONTIEL, Antonio

IPC: A61K38/08 ,  A61K8/64 ,  A61Q19/00 ,  A61Q19/08 ,  A61K9/107 ,  C07K7/06

CPC classification number: C07K7/06 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/1075 ,  A61K9/1272 ,  A61K38/00 ,  A61Q19/00 ,  A61Q19/08

Abstract: Compounds of general formula (I): R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2 (I) their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, cosmetic and/or pharmaceutical compositions which contain them and their use in medicine, and in processes of treatment and/or care of the skin, hair and/or mucous membranes, in particular in the aging and photoaging of the skin.

Abstract translation: 通式（I）的化合物：其中R 1，R 2，R 3，R 4，R 4， 它们的化妆品或药学上可接受的盐，含有它们的化妆品和/或药物组合物及其在药物中的用途，以及治疗和/或护理皮肤，毛发和/或粘膜的方法，特别是在老化和光老化 皮肤。

公开(公告)号：WO2019008452A1

公开(公告)日：2019-01-10

申请号：PCT/IB2018/054015

申请日：2018-06-05

Applicant: LUBRIZOL ADVANCED MATERIALS, INC.

Inventor： DELGADO GONZALEZ, Raquel ,  ALMIÑANA DOMÈNECH, Núria ,  GARCÍA HERNÁNDEZ, Consuelo ,  VALERIO SANTIAGO, Mauricio ,  FERRER MONTIEL, Antonio ,  VAN DEN NEST, Wim ,  RODRÍGUEZ BIELSA, Catalina

IPC: A61K38/08 ,  A61P17/02 ,  A61K8/64 ,  A61Q19/00 ,  A61K8/86

Abstract: A compound of formula (I) R 1 -Wm-Xn-AA 1 -AA 2 -AA 3 -AA 4 -AA 5 -AA 6 -AA 7 -AA 8 -AA 9 -Y p -Z q -R 2 wherein AA 1 is Phe; AA 2 is Trp; AA 3 is selected from the group consisting of Met, Leu and lie; AA 4 is selected from the group consisting of Lys, Arg and Gin; AA 5 is Arg; AA 6 is Lys; AA 7 is selected from the group consisting of Arg, Lys and His; AA 8 is selected from the group consisting of Val, lie, Leu and Met; and AA 9 is Pro, useful in the treatment and/or care of the skin, hair, nails and/or mucous membranes, in particular for improving the barrier function of the skin, for energising the skin and as an anti- aging agent.

公开(公告)号：WO2018071640A1

公开(公告)日：2018-04-19

申请号：PCT/US2017/056300

申请日：2017-10-12

Applicant: LUBRIZOL ADVANCED MATERIALS, INC.

Inventor： VAN DEN NEST, Wim ,  DOMENECH, Nuria Alminana ,  GARCIA, Consuelo ,  FERRER MONTIEL, Antonio Vincente

IPC: C07K5/087 ,  A61K38/04 ,  C07K7/06 ,  C07K5/107

Abstract: The invention relates to a peptide of formula (I) R 1 -W m -X n -AA 1 -AA 2 -AA 3 -Y p -Z q -R 2 , cosmetic or pharmaceutical compositions comprising same and its use, for example, in the reduction of lipid accumulation in the skin, the treatment of cellulite and/or the treatment of the symptoms of skin aging.

Abstract translation: 本发明涉及式（I）的肽R 1 -W m -X n -AA -AA <子> 1 -AA <子> 2 -AA <子> 3 -Y <子> p -Z <子> q -R 包含其的化妆品或药物组合物及其用途，例如用于减少皮肤中的脂质积聚，治疗橘皮组织和/或治疗皮肤老化症状的用途。 p>