公开(公告)号：WO2015053871A8

公开(公告)日：2016-03-31

申请号：PCT/US2014052631

申请日：2014-08-26

Applicant: MABVAX THERAPEUTICS INC

Inventor： SAWADA RITSUKO ,  SUN SHU-MAN ,  SCHOLZ WOLFGANG

IPC: A61K39/395 ,  C07K16/30 ,  C12N15/13

CPC classification number: C07K16/2896 ,  A61K31/337 ,  A61K39/0011 ,  A61K39/39533 ,  A61K39/39558 ,  A61K45/06 ,  A61K51/1027 ,  A61K51/1045 ,  A61K51/1057 ,  A61K51/1093 ,  A61K2039/505 ,  A61K2039/6081 ,  C07K16/28 ,  C07K16/3076 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/626 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57438 ,  G01N33/577

Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against Sialyl-Lewisa (sLea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to sLea. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.

Abstract translation: 本发明提供用于制备针对唾液酸 - Lewisa（sLea）的抗体或其功能片段的组合物。 本发明的组合物包括编码与sLea结合的重链和/或轻链可变结构域的多核苷酸。 本发明还提供了分离的抗体或其功能片段和治疗或预防诸如癌症或肿瘤形成的疾病的方法，其中所述抗体或功能片段包括可变重链结构域和具有氨基酸的可变轻链结构域 序列。 本发明还提供了与诊断试剂，可检测试剂或治疗剂缀合或重组融合的抗体或其功能片段的缀合物，以及在有需要的受试者中治疗，预防或诊断疾病的方法。

公开(公告)号：WO2015053871A4

公开(公告)日：2015-07-30

申请号：PCT/US2014052631

申请日：2014-08-26

Applicant: MABVAX THERAPEUTICS INC

Inventor： SAWADA RITSUKO ,  SUN SHU-MAN ,  SCHOLZ WOLFGANG

IPC: A61K39/395 ,  C07K16/30 ,  C12N15/13

CPC classification number: C07K16/2896 ,  A61K31/337 ,  A61K39/0011 ,  A61K39/39533 ,  A61K39/39558 ,  A61K45/06 ,  A61K51/1027 ,  A61K51/1045 ,  A61K51/1057 ,  A61K51/1093 ,  A61K2039/505 ,  A61K2039/6081 ,  C07K16/28 ,  C07K16/3076 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/626 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57438 ,  G01N33/577

Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against Sialyl-Lewisa (sLea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to sLea. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.

公开(公告)号：WO2015053871A2

公开(公告)日：2015-04-16

申请号：PCT/US2014052631

申请日：2014-08-26

Applicant: MABVAX THERAPEUTICS INC

Inventor： SAWADA RITSUKO ,  SUN SHU-MAN ,  SCHOLZ WOLFGANG

IPC: C07K16/28 ,  A61K39/395

CPC classification number: C07K16/2896 ,  A61K31/337 ,  A61K39/0011 ,  A61K39/39533 ,  A61K39/39558 ,  A61K45/06 ,  A61K51/1027 ,  A61K51/1045 ,  A61K51/1057 ,  A61K51/1093 ,  A61K2039/505 ,  A61K2039/6081 ,  C07K16/28 ,  C07K16/3076 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/626 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57438 ,  G01N33/577

Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against Sialyl-Lewisa (sLea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to sLea. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.

Abstract translation: 本发明提供用于产生针对唾液酸 - Lewisa（sLea）的抗体或其功能片段的组合物。 本发明的组合物包括编码与sLea结合的重链和/或轻链可变结构域的多核苷酸。 本发明还提供了分离的抗体或其功能片段，以及治疗或预防疾病如癌症或肿瘤形成的方法，其中所述抗体或功能片段包含可变重链结构域和具有氨基酸的可变轻链结构域 序列。 本发明还提供了缀合或重组融合到诊断剂，可检测试剂或治疗剂的抗体或其功能片段的缀合物，以及在有此需要的受试者中治疗，预防或诊断疾病的方法。