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公开(公告)号:WO2013106819A3
公开(公告)日:2015-06-18
申请号:PCT/US2013021424
申请日:2013-01-14
Applicant: MASSACHUSETTS INST TECHNOLOGY
Inventor: LIPPARD STEPHEN J , RADFORD ROBERT J
CPC classification number: G01N33/5005 , A61K49/0041 , A61K49/0043 , A61K49/0052 , C07D215/40 , C07D311/82 , C07D405/14 , C07D409/14 , C07K5/10 , C07K7/06 , C07K14/00 , G01N33/84
Abstract: Described herein are compounds and methods useful in the detection of, e.g., Zn2+, in vitro and in vivo. The compounds include amino acids and peptides functionalized with a moiety that binds, e.g., Zn2+. The peptides may be further functionalized with a detectable moiety. The peptides may also comprise amino acid sequences known to localize extracellularly or in specific areas within a cell.
Abstract translation: 本文描述的是用于体外和体内检测例如Zn 2+的化合物和方法。 化合物包括用结合例如Zn 2+的部分官能化的氨基酸和肽。 肽可以用可检测的部分进一步官能化。 肽还可以包含已知在细胞外细胞或特定区域定位的氨基酸序列。