公开(公告)号：WO2019147310A2

公开(公告)日：2019-08-01

申请号：PCT/US2018/049281

申请日：2018-08-31

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： LOVE, J., Christopher ,  MASCARENHAS, Craig, A. ,  ENSHENLU, Amos ,  BRAATZ, Richard, Dean

Abstract: Aspects of the present disclosure relate to filtration systems and methods for production of biologically-produced products, which may include pharmaceutical and/or protein products. Certain biomanufacturing systems described herein comprise a bioreactor (e.g., a perfusion bioreactor, a chemostat) and a filter probe comprising a filter bundle comprising a plurality of hollow fibers (e.g., longitudinally aligned hollow fibers). According to some embodiments, a center-to-center distance between any two hollow fibers within the fiber bundle at one or more points along a length of the fiber bundle is relatively large (e.g., greater than or equal to an average outer diameter of the hollow fibers of the fiber bundle, greater than or equal to 1.1 times a minimum diameter of the two hollow fibers). In some embodiments, the hollow fibers within the fiber bundle are arranged in an array (e.g., a hexagonal, linear, annular, or square array).