公开(公告)号：WO2015119995A1

公开(公告)日：2015-08-13

申请号：PCT/US2015/014377

申请日：2015-02-04

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： IKEDA, Yasuhiro ,  EL KHATIB, Moustafa M.A.

IPC: C12N5/00 ,  C12N5/071 ,  A01N63/00

CPC classification number: C12N5/0676 ,  C12N5/0678 ,  C12N5/0696 ,  C12N2501/105 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/335 ,  C12N2501/41 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/734 ,  C12N2501/999 ,  C12N2506/094 ,  C12N2506/45 ,  C12N2510/00

Abstract: This document provides methods and materials related to making and using differentiated induced pluripotent stem cells. For example, methods and materials for making differentiated induced pluripotent stem cells (e.g., insulin-producing cells) that do not form cancer cells within a mammal (e.g., a human), cells that underwent guided differentiation from induced pluripotent stem cells, compositions containing cells that underwent guided differentiation from induced pluripotent stem cells, and methods for using cells that underwent guided differentiation from induced pluripotent stem cells (e.g., methods for using such cells to treat diabetes or to repair cardiovascular tissue) are provided.

Abstract translation: 本文提供了与使用分化诱导多能干细胞相关的方法和材料。 例如，用于制造在哺乳动物（例如人）内不形成癌细胞的分化诱导多能干细胞（例如，产生胰岛素的细胞）的方法和材料，经受诱导的多能干细胞分化的细胞，含有 提供了从诱导多能干细胞引导分化的细胞，以及使用经诱导的多能干细胞引导分化的细胞的方法（例如，使用这种细胞治疗糖尿病或修复心血管组织的方法）。