公开(公告)号：WO2022178633A1

公开(公告)日：2022-09-01

申请号：PCT/CA2022/050262

申请日：2022-02-24

Applicant: MCMASTER UNIVERSITY

Inventor： RULLO, Anthony ,  WAN, Yonghong ,  MCNULTY, James ,  LAKE, Benjamin ,  ZHANG, Ruijia ,  KAPCAN, Eden ,  WALSH, Scott

IPC: C07K7/08 ,  A61K39/385 ,  A61P31/14 ,  A61P37/02

Abstract: The present disclosure relates generally to the field of antiviral immunotherapy. More particularly, the present disclosure provides Antibody Recruitment Molecules (ARMs) for targeted recruitment of endogenous antibodies to virions and/or virus-infected cells, pharmaceutical compositions comprising same and methods of treating Coronavirus Disease 2019 (COVID-19) using same.

公开(公告)号：WO2022178638A1

公开(公告)日：2022-09-01

申请号：PCT/CA2022/050267

申请日：2022-02-24

Applicant: MCMASTER UNIVERSITY

Inventor： RULLO, Anthony ,  WAN, Yonghong ,  MCCANN, Harrison ,  LAKE, Benjamin

IPC: C07K19/00 ,  A61K39/385 ,  A61P35/00 ,  A61P37/02

Abstract: The present disclosure relates generally to the field of cancer immunotherapy. More particularly, the present disclosure provides antibody recruitment molecules, pharmaceutical compositions comprising same and kits comprising same. The present disclosure also provides methods of treating cancer using the antibody recruitment molecules in combination with oncolytic virus therapy, and methods for enhancing the efficacy and/or reducing the toxicity of the oncolytic virus therapy.