公开(公告)号：WO2008147551A8

公开(公告)日：2010-01-07

申请号：PCT/US2008006667

申请日：2008-05-23

申请人： MEDIVATION NEUROLOGY INC ,  HUNG DAVID T ,  PROTTER ANDREW ASHER

发明人： HUNG DAVID T ,  PROTTER ANDREW ASHER

IPC分类号： A61K31/44

CPC分类号： A61K31/44

摘要： The invention provides compositions and methods for treating, preventing, delaying the onset, and/or delaying the development of a disease or condition for which the activation, differentiation, and/or proliferation of one or more cell types is beneficial. These compositions and methods include, for example, a hydrogenated pyrido [4,3 -b] indole such as dimebon and/or a cell that has been incubated with a hydrogenated pyrido [4,3 -b] indole such as dimebon. In some embodiments, the compositions and methods also include a growth factor and/or an anti-cell death compound. The invention also provides methods of activating a cell, promoting the differentiation of a cell, and/or promoting the proliferation of a cell by incubating the cell with one or more hydrogenated pyrido [4,3 -b] indoles or pharmaceutically acceptable salts thereof. In some embodiments, the cell is also incubated with one or more growth factors and/or anti-cell death compounds.

摘要翻译： 本发明提供用于治疗，预防，延缓发作和/或延缓一种或多种细胞类型的活化，分化和/或增殖有益的疾病或病症的发展的组合物和方法。 这些组合物和方法包括例如氢化吡啶并[4,3-b]吲哚（如二甲氧基）和/或已经与氢化吡啶并[4,3-b]吲哚（如二甲氧基）温育的细胞。 在一些实施方案中，组合物和方法还包括生长因子和/或抗细胞死亡化合物。 本发明还提供了通过将细胞与一种或多种氢化吡啶并[4,3-b]吲哚或其药学上可接受的盐一起孵育来激活细胞，促进细胞分化和/或促进细胞增殖的方法。 在一些实施方案中，细胞还与一种或多种生长因子和/或抗细胞死亡化合物一起温育。

公开(公告)号：WO2008051599A2

公开(公告)日：2008-05-02

申请号：PCT/US2007022645

申请日：2007-10-26

申请人： MEDIVATION INC ,  HUNG DAVID T ,  PROTTER ANDREW ASHER

发明人： HUNG DAVID T ,  PROTTER ANDREW ASHER

CPC分类号： A61K31/437 ,  A61K31/445 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides methods and combination therapies for treating and/or preventing and/or slowing the onset and/or development of Alzheimer's disease using a hydrogenated pyrido (4,3-b) indole (e.g., dimebon) in conjunction with another compound, pharmaceutically acceptable salt thereof or therapy for Alzheimer's disease.

摘要翻译： 本发明提供了使用氢化吡啶并（4,3-b）吲哚（例如，二甲氧基）与另一种化合物结合治疗和/或预防和/或预防和/或预防和/或减缓阿尔茨海默氏病的发病和/或发展的方法和组合疗法 可接受的盐或阿尔茨海默氏病的治疗。

公开(公告)号：WO2009094668A8

公开(公告)日：2010-09-10

申请号：PCT/US2009032065

申请日：2009-01-26

申请人： MEDIVATION TECHNOLOGIES INC ,  HUNG DAVID T ,  PROTTER ANDREW ASHER ,  CHAKRAVARTY SARVAJIT ,  JAIN RAJENDRA PARASMAL

发明人： HUNG DAVID T ,  PROTTER ANDREW ASHER ,  CHAKRAVARTY SARVAJIT ,  JAIN RAJENDRA PARASMAL

IPC分类号： A61K31/4745 ,  C07D471/02

CPC分类号： C07D487/14 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04

摘要： This disclosure relates to new tricyclic compounds that may be used to modulate a histamine receptor in an individual. Compounds are described, including new 2,3,4,5- tetrahydro-lH-pyrido[4,3-b]indole compounds. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

摘要翻译： 本公开涉及可用于调节个体中组胺受体的新型三环化合物。 描述了化合物，包括新的2,3,4,5-四氢-1H-吡啶并[4,3-b]吲哚化合物。 还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

公开(公告)号：WO2009120717A3

公开(公告)日：2009-12-03

申请号：PCT/US2009038138

申请日：2009-03-24

申请人： MEDIVATION TECHNOLOGIES INC ,  HUNG DAVID T ,  PROTTER ANDREW ASHER ,  CHAKRAVARTY SARVAJIT ,  JAIN RAJENDRA PARASMAL ,  DUGAR SUNDEEP

发明人： HUNG DAVID T ,  PROTTER ANDREW ASHER ,  CHAKRAVARTY SARVAJIT ,  JAIN RAJENDRA PARASMAL ,  DUGAR SUNDEEP

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P25/00

CPC分类号： C07D471/14 ,  C07D471/04

摘要： This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

摘要翻译： 本公开涉及可用于调节个体中组胺受体的新杂环化合物。 描述吡啶并[3,4-b]吲哚，以及包含该化合物的药物组合物以及在各种治疗应用中使用该化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或 神经元紊乱。

公开(公告)号：WO2009039420A1

公开(公告)日：2009-03-26

申请号：PCT/US2008077090

申请日：2008-09-19

申请人： MEDIVATION NEUROLOGY INC ,  HUNG DAVID T

发明人： HUNG DAVID T

IPC分类号： A01N43/38 ,  A61K31/405

CPC分类号： A61K31/405

摘要： The invention provides methods for treating and/or preventing and/or slowing the onset and/or development of a neuronal death mediated ocular disease using hydrogenated pyrido[4,3- b]indoles, such as dimebon.

摘要翻译： 本发明提供了使用氢化吡啶并[4,3-b]吲哚（例如Dimebon）治疗和/或预防和/或减缓神经元死亡介导的眼部疾病的发生和/或发展的方法。