公开(公告)号：WO02094334B1

公开(公告)日：2003-02-13

申请号：PCT/US0216136

申请日：2002-05-21

Applicant: MEDTRONIC INC

Inventor： SKARDA JAMES R

IPC: A61B18/14 ,  A61L29/02 ,  A61L31/02 ,  A61M25/00 ,  C22C14/00

CPC classification number: A61M25/0041 ,  A61B18/1492 ,  A61B2018/00386 ,  A61L29/02 ,  A61L31/022 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/008 ,  A61M25/0082 ,  A61M25/09 ,  A61M2025/0063 ,  A61M2025/09141 ,  A61M2205/0266 ,  C22C14/00

Abstract: An elongated medical device insertable through an access pathway into a body vessel, organ or cavity to locate a therapeutic or diagnostic distal segment of the elongated medical device into alignment with an anatomic feature of interest having a malleable distal segment capable of being manually formed into a shape facilitating such alignment at room temperature. The elongated medical device includes a device body distal section formed of a malleable material including an elongated, malleable member disposed on or within the device body extending in the direction of the device body axis. The malleable member is formed of a Beta III titanium alloy of the type exhibiting superelastic properties when subjected to strain at a bending strain of less than a set threshold strain and capable of undergoing plastic flow to take a set shape when subjected to a strain of greater than the set threshold at the same temperature.

Abstract translation: 细长的医疗装置可以通过进入通道插入身体容器，器官或空腔中，以将细长的医疗装置的治疗或诊断远侧段定位成与感兴趣的解剖特征对准，具有可延展的远端段，其能够手动形成为 形状有助于在室温下进行这种对准。 细长的医疗装置包括由可延展材料形成的装置主体远端部分，其包括设置在装置本体上或装置本体轴线方向上延伸的细长的可延展部件。 该韧性构件由具有超弹性特性的βIII型钛合金形成，当经受小于设定阈值应变的弯曲应变下的应变时，当受到较大应变时，能够经受塑性流动以形成一定形状 在相同温度下的设定阈值。

公开(公告)号：WO2007140331A3

公开(公告)日：2008-01-17

申请号：PCT/US2007069789

申请日：2007-05-25

Applicant: MEDTRONIC INC ,  STEWART MARK T ,  FRANCISCHELLI DAVID E ,  KEOGH JAMES R ,  HISSONG JAMES B ,  SKARDA JAMES R ,  LEE HOTAIK ,  SMITH NADINE B

Inventor： STEWART MARK T ,  FRANCISCHELLI DAVID E ,  KEOGH JAMES R ,  HISSONG JAMES B ,  SKARDA JAMES R ,  LEE HOTAIK ,  SMITH NADINE B

IPC: A61N7/02

CPC classification number: A61B17/320068 ,  A61B8/4281 ,  A61B34/20 ,  A61B2017/320076 ,  A61B2017/320078 ,  A61B2018/00291 ,  A61B2034/2051 ,  A61B2090/378 ,  A61B2090/3782 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

Abstract: A device and method for ablating tissue is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding an ablating member within the patient while tracking the position of the ablating member in the patient, positioning the ablating member in a desired position to ablate tissue, emitting ablating energy from the ablating member to form an ablated tissue area and removing the ablating member from the patient.

Abstract translation: 公开了一种用于消融组织的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪患者内的消融部件的位置的同时引导患者内的消融部件，定位消融 成员在消融组织的期望位置，从烧蚀构件发出消融能量以形成消融的组织区域，并从患者身上移除消融部件。

公开(公告)号：WO0245608A2

公开(公告)日：2002-06-13

申请号：PCT/US0144977

申请日：2001-11-30

Applicant: MEDTRONIC INC

Inventor： STEWART MARK T ,  SKARDA JAMES R ,  FLICKINGER WILLIAM J ,  FRANCISCHELLI DAVID E

IPC: A61B17/00 ,  A61B18/14

CPC classification number: A61B18/1492 ,  A61B2017/00044 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00375 ,  A61B2018/1407 ,  A61B2018/1435

Abstract: A catheter assembly and method for treatment of cardiac arrhythmia. In one preferred embodiment, the catheter assembly includes a cetheter body, at least one electrode, and a fluid source. The catheter body includes a proximal portion, an intermediate portion, a distal portion, a first lumen, and an ablation section. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and forms a helix or coil. The first lumen extends from the proximal portion to the distal portion. Finally, the ablation section is formed along the helix of the distal portion and defines a loop transverse to the longitudinal axis. The ablation section is, in one preferred embodiment, comprised of a microporous material in fluid communication with the first lumen so as to irrigate fluid from the first lumen to an exterior surface of the ablation section. The electrode is associated with the ablation section. Finally, the fluid source is provided to supply a conductive fluid to the first lumen. With the configuration, upon activation, the electrode supplies an ablation energy to fluid irrigated to the exterior surface of the ablation section, thereby ablating a continuous, closed lesion pattern. During use, for example, the catheter assembly can ablate a closed lesion pattern corresponding with the loop defined by the ablation section on a chamber wall about a pulmonary vein ostium to electrically isolate the pulmonary vein from the left atrium. In one preferred embodiment, the ablation section is comprised of a high density, expanded PTFE material. In another preferred embodiment, a shaping wire is slidably disposed within the catheter body to selectively dictate the desired helical shape of the distal portion.

Abstract translation: 一种用于治疗心律失常的导管组件和方法。 在一个优选实施例中，导管组件包括绦虫体，至少一个电极和流体源。 导管主体包括近端部分，中间部分，远端部分，第一内腔和消融部分。 中间部分从近端部分延伸并且限定纵向轴线。 远侧部分从中间部分延伸并形成螺旋或线圈。 第一管腔从近端部分延伸到远端部分。 最后，消融部分沿着远侧部分的螺旋形成并且限定了一个横向于纵向轴线的环。 在一个优选实施例中，消融部分包括与第一内腔流体连通的微孔材料，以便将流体从第一内腔冲洗到消融部分的外表面。 电极与消融部分相关联。 最后，提供流体源以向第一管腔提供导电流体。 利用该构造，在激活时，电极将消融能量提供给冲洗到消融部分的外表面的流体，从而消除连续的闭合病变图案。 在使用期间，例如，导管组件可以消除对应于围绕肺静脉口的腔室壁上的消融部分限定的环的封闭病变图案，以将肺静脉与左心房电隔离。 在一个优选实施例中，消融部分由高密度，膨胀的PTFE材料组成。 在另一优选实施例中，成形线可滑动地设置在导管主体内，以选择性地决定远侧部分的期望的螺旋形状。

公开(公告)号：WO2007067945A8

公开(公告)日：2009-08-20

申请号：PCT/US2006061722

申请日：2006-12-07

Applicant: MEDTRONIC INC ,  FRANCISCHELLI DAVID E ,  HISSONG JAMES B ,  KEOGH JAMES R ,  SKARDA JAMES R ,  STEWART MARK T

Inventor： FRANCISCHELLI DAVID E ,  HISSONG JAMES B ,  KEOGH JAMES R ,  SKARDA JAMES R ,  STEWART MARK T

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61B8/4272 ,  A61B18/1442 ,  A61B34/20 ,  A61B2017/00243 ,  A61B2018/00291 ,  A61B2034/2051 ,  A61B2034/2053 ,  A61B2034/2063 ,  A61B2090/378 ,  A61B2090/397 ,  A61N7/022 ,  A61N2007/0078

公开(公告)号：WO02094363A3

公开(公告)日：2003-02-06

申请号：PCT/US0216142

申请日：2002-05-21

Applicant: MEDTRONIC INC

Inventor： STEWART MARK T ,  FRANCISCHELLI DAVID E ,  SKARDA JAMES R

IPC: A61B17/00 ,  A61F2/958 ,  A61M25/10

CPC classification number: A61B17/00234 ,  A61B2017/00252 ,  A61M25/10

Abstract: A trans-septal guide catheter for providing access through the septum separating a first heart chamber from a second heart chamber that includes an elongated guide catheter body extending between guide catheter proximal and distal ends. A distal segment of the guide catheter is adapted to be inserted through the septum to locate the distal segment of the guide catheter within one of the first heart chamber and the second heart chamber. The catheter body encloses a guide catheter lumen adapted to provide access into the one of the first heart chamber and the second heart chamber through a guide catheter lumen proximal end opening and a guide catheter lumen distal end opening. A retention mechanism engages the septum and maintains the distal segment of the guide catheter extending into the one of the first heart chamber and the second heart chamber.

Abstract translation: 一种反间隔导引导管，用于提供通过将第一心室与第二心室隔开的隔膜的通路，该第二心室包括在引导导管近端和远端之间延伸的细长引导导管主体。 引导导管的远侧部分适于插入穿过隔膜以将引导导管的远侧部分定位在第一心室和第二心室之一内。 导管主体包围引导导管内腔，其适于通过引导导管内腔近端开口和引导导管内腔远端开口提供通向第一心室和第二心室之一的通路。 保持机构接合隔膜并且保持引导导管的远端段延伸到第一心室和第二心室中的一个。

公开(公告)号：WO2004058341A2

公开(公告)日：2004-07-15

申请号：PCT/US0340635

申请日：2003-12-19

Applicant: MEDTRONIC INC

Inventor： WALDHAUSER STEVEN L ,  GESKE JEFF ,  TEISANU EDUARD T ,  SKARDA JAMES R ,  SHIPE GREGORY P

IPC: A61M25/00

CPC classification number: A61M25/0012 ,  A61M25/0029 ,  A61M25/005 ,  A61M25/0053 ,  A61M25/0054 ,  A61M25/0147 ,  A61M2025/0034 ,  A61M2025/0037 ,  A61M2025/0177 ,  A61M2025/018

Abstract: A steerable catheter and methods of fabrication including a catheter body formed of a continuous wire braid formed of wires braided over a delivery lumen liner and a pull wire lumen liner distal to a pull wire jacket port, braided around the pull wire jacket port to form a braid port, and over at least a portion of the delivery lumen liner proximal to the pull wire jacket port. A pull wire extends from a pull wire proximal end through the pull wire lumen port and through the pull wire lumen to a pull wire distal end. A band is attached to the pull wire distal end and fitted over a distal segment of the wire braid proximal to the catheter body distal end to fix the pull wire distal end to the catheter body and restrain the wire distal end from flaring away from the delivery lumen liner.

Abstract translation: 一种可导向的导管和制造方法，包括导线管主体，该引导体由连续导线编织物形成，该导线编织物由编织在输送内腔衬垫上的导线和拉线内腔衬套组成，拉线线束衬套位于拉线护套端口的外侧，围绕拉线护套端口编织以形成 编织端口，以及靠近拉线护套端口的至少一部分输送腔衬里。 拉线从拉线近端延伸穿过拉丝管腔端口并且通过拉线管腔延伸到拉线远端。 带子附接到拉线远端并且装配在靠近导管主体远端的导线编织物的远侧段上，以将拉线远端固定到导管主体并且限制线远端远离输送 流明衬垫。

公开(公告)号：WO0245608A9

公开(公告)日：2003-12-18

申请号：PCT/US0144977

申请日：2001-11-30

Applicant: MEDTRONIC INC

Inventor： STEWART MARK T ,  SKARDA JAMES R ,  FLICKINGER WILLIAM J ,  FRANCISCHELLI DAVID E

IPC: A61B17/00 ,  A61B18/14

CPC classification number: A61B18/1492 ,  A61B2017/00044 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00375 ,  A61B2018/1407 ,  A61B2018/1435

Abstract: A catheter assembly and method for treatment of cardiac arrhythmia. In one preferred embodiment, the catheter assembly includes a cetheter body, at least one electrode, and a fluid source. The catheter body includes a proximal portion, an intermediate portion, a distal portion, a first lumen, and an ablation section. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and forms a helix or coil. The first lumen extends from the proximal portion to the distal portion. Finally, the ablation section is formed along the helix of the distal portion and defines a loop transverse to the longitudinal axis. The ablation section is, in one preferred embodiment, comprised of a microporous material in fluid communication with the first lumen so as to irrigate fluid from the first lumen to an exterior surface of the ablation section. The electrode is associated with the ablation section. Finally, the fluid source is provided to supply a conductive fluid to the first lumen. With the configuration, upon activation, the electrode supplies an ablation energy to fluid irrigated to the exterior surface of the ablation section, thereby ablating a continuous, closed lesion pattern. During use, for example, the catheter assembly can ablate a closed lesion pattern corresponding with the loop defined by the ablation section on a chamber wall about a pulmonary vein ostium to electrically isolate the pulmonary vein from the left atrium. In one preferred embodiment, the ablation section is comprised of a high density, expanded PTFE material. In another preferred embodiment, a shaping wire is slidably disposed within the catheter body to selectively dictate the desired helical shape of the distal portion.

Abstract translation: 一种用于治疗心律失常的导管组件和方法。 在一个优选实施例中，导管组件包括绦虫体，至少一个电极和流体源。 导管主体包括近端部分，中间部分，远端部分，第一内腔和消融部分。 中间部分从近侧部分延伸并且限定纵向轴线。 远侧部分从中间部分延伸并形成螺旋或线圈。 第一管腔从近端部分延伸到远端部分。 最后，消融部分沿着远侧部分的螺旋形成，并且限定了一个横向于纵轴的环。 在一个优选实施例中，消融部分包括与第一内腔流体连通的微孔材料，以便将流体从第一内腔冲洗到消融部分的外表面。 电极与消融部分相关联。 最后，提供流体源以向第一管腔提供导电流体。 利用该配置，在激活时，电极将消融能量提供给冲洗到消融部分的外表面的流体，从而消除连续的闭合病变图案。 在使用期间，例如，导管组件可以消除对应于围绕肺静脉口的腔室壁上的消融部分限定的环的封闭病变图案，以将肺静脉与左心房电隔离。 在一个优选实施例中，消融部分由高密度，膨胀的PTFE材料组成。 在另一优选实施例中，成形线可滑动地设置在导管主体内，以选择性地决定远侧部分的期望的螺旋形状。

公开(公告)号：WO02087452A2

公开(公告)日：2002-11-07

申请号：PCT/US0213166

申请日：2002-04-25

Applicant: MEDTRONIC INC

Inventor： FRANSISCHELLI DAVID E ,  SKARDA JAMES R ,  STEWART MARK T ,  MEHR RAHUL

IPC: A61B18/12 ,  A61B18/00

CPC classification number: A61B18/1206 ,  A61B18/1445 ,  A61B2018/0016 ,  A61B2018/00351 ,  A61B2018/00363 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/1467 ,  A61B2218/002

Abstract: A system and method for creating lesions and assessing their completeness or transmurality. Assessment of transmurality of a lesion is accomplished by monitoring the impedance of the tissue to be ablated. Rather than attempting to detect a desired drop or a desired increase impedance, completeness of a lesion is detected in response to the measured impedance remaining at a stable level for a desired period of time, referred to as an impedance plateau. The mechanism for determining transmurality of lesions adjacent individual electrodes or pairs may be used to deactivate individual electrodes or electrode pairs, when the lesions in tissue adjacent these individual electrodes or electrode pairs are complete, to create an essentially uniform lesion along the line of electrodes or electrode pairs, regardless of differences in tissue thickness adjacent the individual electrodes or electrode pairs.

Abstract translation: 用于创建病变并评估其完整性或透视性的系统和方法。 通过监测要消融的组织的阻抗来评估病变的透壁性。 不是试图检测到期望的下降或期望的增加阻抗，而是响应于被测量的阻抗保持在稳定的电平，在期望的时间段（被称为阻抗平台）来检测损伤的完整性。 当邻近这些单个电极或电极对的组织中的损伤完整时，用于确定相邻个体电极或对的损伤的透壁性的机制可用于使单个电极或电极对失活，以产生沿着电极线的基本均匀的损伤或 电极对，而不管邻近各个电极或电极对的组织厚度的差异。