公开(公告)号：WO2016081534A1

公开(公告)日：2016-05-26

申请号：PCT/US2015/061215

申请日：2015-11-18

Applicant: METABOLON, INC.

Inventor： PERICHON, Regis ,  BELL, Lauren, Nicole ,  WULFF, Jacob ,  NGUYEN, Uyen, Thao ,  WATKINS, Steven, M.

IPC: C12Q1/00 ,  G01N33/50 ,  G01N33/68

CPC classification number: G01N33/92 ,  G01N33/50 ,  G01N33/5023 ,  G01N33/6806 ,  G01N33/82 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/085 ,  G01N2800/56 ,  G01N2800/7052

Abstract: Biomarkers of NASH, NAFLD, and fibrosis and methods for diagnosis (or aiding in the diagnosis) of NAFLD, NASH and/or fibrosis are described herein. Additionally, methods of distinguishing between NAFLD and NASH, methods of classifying the stage of fibrosis, methods of determining the severity of liver disease, methods of determining the severity of liver disease or fibrosis, and methods of monitoring progression/regression of NASH, NAFLD, and/or fibrosis are described herein.

Abstract translation: 本文描述了NASH，NAFLD和纤维化的生物标志物和NAFLD，NASH和/或纤维化的诊断（或辅助诊断）的方法。 另外，区分NAFLD和NASH的方法，分类纤维化阶段的方法，确定肝脏疾病严重程度的方法，确定肝病或纤维化严重程度的方法，以及监测NASH，NAFLD， 和/或纤维化。

公开(公告)号：WO2015095451A1

公开(公告)日：2015-06-25

申请号：PCT/US2014/071035

申请日：2014-12-18

Applicant: METABOLON, INC.

Inventor： WATKINS, Steven, M.

IPC: A61K35/60 ,  A61P35/04 ,  G01N33/50

CPC classification number: G01N33/92 ,  G01N2405/00 ,  G01N2800/7085

Abstract: Biomarkers relating to de novo lipogenesis are provided, as well as methods for using such biomarkers in an Index to assess DNL. In addition, methods for diagnosing, determining predisposition to, and monitoring progression/regression of diseases related to DNL are provided. Also provided are methods of monitoring the efficacy of treatments for diseases related to DNL as well as other methods based on biomarkers of DNL.

Abstract translation: 提供与新生脂肪生成有关的生物标志物，以及在索引中使用这些生物标志物评估DNL的方法。 此外，还提供了诊断，确定与DNL相关疾病的倾向和监测进展/退化的方法。 还提供了监测与DNL相关疾病的治疗功效以及基于DNL生物标志物的其它方法的方法。