公开(公告)号：WO1996002317A1

公开(公告)日：1996-02-01

申请号：PCT/US1995009836

申请日：1995-07-19

Applicant: MILLIPORE CORPORATION

Inventor： MILLIPORE CORPORATION ,  TUCCELLI, Ronald ,  MCGRATH, Paul, V.

IPC: B01D71/10

CPC classification number: B01D69/12 ,  B01D71/14 ,  B01D71/16

Abstract: A cellulosic ultrafiltration membrane is provided having a microporous base resistant substrate and an ultrafiltration layer form of a cellulose ester or cellulose.

Abstract translation: 提供了具有微孔耐碱底物和纤维素酯或纤维素的超滤层形式的纤维素超滤膜。

公开(公告)号：WO1995027195A1

公开(公告)日：1995-10-12

申请号：PCT/US1995003751

申请日：1995-03-29

Applicant: MILLIPORE CORPORATION

Inventor： MILLIPORE CORPORATION ,  GAGNE, Helen, Marie

IPC: G01N01/34

CPC classification number: B01L99/00 ,  B01D65/00 ,  G01N1/286 ,  G01N2001/288

Abstract: A membrane cutter and retriever (10) is disclosed which includes a hollow circular die (12) securely fastened through a hollow connector (13) to the luer opening (16) of a syringe (15). The die/syringe assembly (10) is inserted within a filter holder unit (20) having a membrane (22) secured to the bottom thereof. The die (12) contacts the periphery of the membrane and is rotated to cut and release the membrane from the holder unit. The plunger of the syringe is then raised to create a vacuum which forces the cut membrane into the hollow die where it is retained until such time as the plunger is lowered to create sufficient pressure to deposit the membrane at a desired location for subsequent analysis.

Abstract translation: 公开了一种膜切割器和回收器（10），其包括通过中空连接器（13）牢固地紧固到注射器（15）的鲁尔开口（16）的中空圆形模具（12）。 模具/注射器组件（10）插入具有固定到其底部的膜（22）的过滤器保持器单元（20）内。 模具（12）接触膜的周边并旋转以从保持器单元切割并释放膜。 然后将注射器的柱塞升高以产生真空，迫使切割的膜进入中空模具，直到其被保持直到柱塞降低的时间以产生足够的压力以将膜沉积在期望的位置用于随后的分析。

公开(公告)号：WO1995032379A1

公开(公告)日：1995-11-30

申请号：PCT/US1995006401

申请日：1995-05-23

Applicant: MILLIPORE CORPORATION

Inventor： MILLIPORE CORPORATION ,  BOWERS, William, F.

IPC: F16K25/02

CPC classification number: B01D53/0446 ,  B01D2253/206 ,  B01D2259/40005 ,  B01D2259/40081 ,  B01D2259/4061 ,  B01D2259/4065 ,  B01D2259/4068 ,  F16K11/074 ,  F16K25/02 ,  Y10T137/4259 ,  Y10T137/4442 ,  Y10T137/86501

Abstract: A sanitary slider valve shown specifically as a rotary carousel diaphragm valve which has a thermoplastic elastomeric diaphragm (230) integrally molded to form the multiple sealing ports of the rotor/stator interface is described. Ports or grooves molded into the face of the elastomeric diaphragm are positioned to sealably engage grooves or ports in the stator face, and to form sanitary elastomeric tubular ducts leading through the body of the rotor or of the stator, terminating as elastomeric flanges. These flanges permit direct connection to sanitary flared piping flanges within the carousel which lead to and from multiple columns or other solid phase bed segments, or to sanitary flared piping flanges connecting the stator to piping interconnecting the multiple carousel columns to each other and to external supply and collection lines. Sanitary operation is made operable by energized flexible diaphragm wiping lip seals (222) which maintain fluid-tight sealing engagement with the opposing face even when the rotor (201) is lifted off the stator (300) far enough to permit cross flushing of the port sealing faces with sanitizing fluid. The valve permits sanitary operation of advanced chromatographic separations of biopharmaceuticals, including simulated moving bed chromatography.

Abstract translation: 具体地示出为具有一体模制以形成转子/定子界面的多个密封端口的热塑性弹性膜（230）的旋转圆盘传送带隔膜阀的卫生滑块阀被描述。 模制在弹性膜片表面上的端口或凹槽被定位成可密封地接合定子面中的凹槽或端口，并且形成通向转子或定子的主体的卫生橡胶管状导管，终止于弹性体凸缘。 这些法兰允许直接连接到转盘内的多个柱或其他固相床段的卫生间扩张管道法兰，或连接定子与将多个转盘柱相互连接的管道与外部供应 和收集线。 即使当转子（201）从定子（300）上离开足够远以允许端口交叉冲洗时，卫生操作可通过通电柔性隔膜擦拭唇形密封件（222）进行操作，从而保持与相对面的流体密封密封接合 密封面与消毒液。 该阀允许卫生操作先进的生物药物色谱分离，包括模拟移动床层析。

公开(公告)号：WO1995022399A1

公开(公告)日：1995-08-24

申请号：PCT/US1995002178

申请日：1995-02-15

Applicant: MILLIPORE CORPORATION

Inventor： MILLIPORE CORPORATION ,  STANKOWSKI, Ralph ,  MILCETICH, John

IPC: B01D63/08

CPC classification number: B01D63/087 ,  B01D29/05 ,  B01D63/08 ,  B01D2201/4084 ,  Y10S264/48

Abstract: A membrane support apparatus is provided which includes a top section, a mating base section and a membrane support surface within the mated sections. The apparatus includes a first peripheral seal formed by extension on one of the sections which mates with a groove on the other of the sections, a second seal formed by a smooth surface on either the groove or the extension which mates with a bead on the other of the groove or extension to form a second peripheral seal. The top section and the base section optionally can form a third peripheral seal about the periphery of a membrane on the membrane support surface.

Abstract translation: 提供一种膜支撑装置，其包括顶部，配合基部和配合部分内的膜支撑表面。 该装置包括第一外围密封件，该第一外围密封件由在与另一个部分上的凹槽相配合的部分之间延伸形成，第二密封件由凹槽或延伸部上的光滑表面形成，与另一个上的珠缘配合 的凹槽或延伸部分以形成第二周边密封件。 顶部和底部部分可任选地围绕膜支撑表面上的膜的周边形成第三周边密封。

公开(公告)号：WO1985000987A1

公开(公告)日：1985-03-14

申请号：PCT/US1984001360

申请日：1984-08-24

Applicant: MILLIPORE CORPORATION

Inventor： MILLIPORE CORPORATION ,  RISING, Donald, Brewster ,  NAEGELI, Richard, G., Jr.

IPC: B01D19/00

CPC classification number: B01D19/0031 ,  A61M5/165 ,  A61M5/38 ,  A61M2005/1657 ,  A61M2205/7527 ,  A61M2205/7536

Abstract: A filter apparatus which is adapted for filtration of intravenous liquids and separates gas in the incoming intravenous liquid prior to delivering the filtered liquid to a patient. Incoming liquid is passed into a space within a filter holder (10), which space has a smaller portion (27) that excludes gas due to surface tension forces and a larger portion (26) where gas accumulates. A hydrophobic filter membrane (18) is positioned adjacent the large portion of the space to permit passage of gas from the space. A hydrophilic filter membrane (16) is positioned within the space to filter the liquid prior to administration to the patient.

公开(公告)号：WO1998006765A1

公开(公告)日：1998-02-19

申请号：PCT/US1997013514

申请日：1997-07-31

Applicant: MILLIPORE CORPORATION

Inventor： MILLIPORE CORPORATION ,  CHARKOUDIAN, John

IPC: C08F283/00

CPC classification number: C08F283/00 ,  C08F283/02 ,  C08G75/20 ,  H05K1/0333

Abstract: A polysulfone composition is formed from a solution of a polysulfone and a free radical polymerizable monomer exposed to ultraviolet light to form a blend of the polysulfone and copolymers of activated polysulfone and polymerized monomer having polymer segments covalently bonded to each other. The blend is separated from solvent of the solution to form a solid comprising the blend throughout its bulk matrix.

Abstract translation: 聚砜组合物由聚砜和暴露于紫外线的自由基可聚合单体的溶液形成，以形成聚砜和活性聚砜与具有彼此共价键合的聚合物链段的聚合单体的共聚物的共混物。 将共混物与溶液的溶剂分离，以形成包含其整个整体基质中的共混物的固体。

公开(公告)号：WO1997030809A1

公开(公告)日：1997-08-28

申请号：PCT/US1996020904

申请日：1996-12-13

Applicant: MILLIPORE CORPORATION

Inventor： MILLIPORE CORPORATION ,  ZELLER, Robert, S. ,  VROMAN, Christopher, J.

IPC: B22F01/00

CPC classification number: B01D67/0041 ,  B01D39/06 ,  B01D39/2034 ,  B01D39/2044 ,  B01D39/2075 ,  B01D71/022 ,  B22F1/0096 ,  B22F2009/045 ,  B22F2998/10 ,  B22F9/04

Abstract: A method for forming dendritic metal powders, comprising the steps of: (1) heating a powder comprising non-dendritic particles, under conditions suitable for initial stage sintering, to form a lightly sintered material; and (2) breaking the lightly sintered material to form a powder comprising dendritic particles. In one embodiment, the lightly sintered material is broken by brushing the material through a screen. Another aspect of the present invention comprises the dendritic particles that are produced by the method described above. These particles can comprise any suitable metal, such as transition metals, rare earth metals, main group metals or metalloids or an alloy of two or more such metals. The particles can also comprise a ceramic material, such as a metal oxide. These particles are characterized by a dendritic, highly anisotropic, morphology arising from the fusion of substantially non-dendritic particles, and by a low apparent density relative to the substantially non-dendritic starting material. The present dendritic particles can be of high purity, and substantially free of carbon contamination.

Abstract translation: 一种形成树枝状金属粉末的方法，包括以下步骤：（1）在适于初始阶段烧结的条件下加热包含非树枝状颗粒的粉末，以形成轻烧结材料; 和（2）破碎轻烧结的材料以形成包含树枝状颗粒的粉末。 在一个实施例中，通过用屏幕刷涂材料来破坏轻度烧结材料。 本发明的另一方面包括通过上述方法制备的树枝状颗粒。 这些颗粒可以包括任何合适的金属，例如过渡金属，稀土金属，主族金属或准金属或两种或更多种这种金属的合金。 颗粒还可以包含陶瓷材料，例如金属氧化物。 这些颗粒的特征在于由基本上非树枝状颗粒的融合产生的树枝状，高度各向异性的形态，以及相对于基本上非树枝状起始材料的低表观密度。 本发明的树枝状颗粒可以是高纯度的，并且基本上没有碳污染。

公开(公告)号：WO1996001999A1

公开(公告)日：1996-01-25

申请号：PCT/US1995009463

申请日：1995-07-10

Applicant: MILLIPORE CORPORATION

Inventor： MILLIPORE CORPORATION ,  FOLLEY, Adam, D.

IPC: G01N33/18

CPC classification number: G01N33/1846 ,  G01N27/021 ,  G01N27/06 ,  G01N27/08

Abstract: Methods are presented for obtaining the amount of total organic carbon in a water supply. In one method the amount of total organic carbon is calculated from a proportionality relationship between resistivity measurements and a previously determined assessment of resistivity for a water sample where all the organic carbon is completely oxidized. In another method the amount of total organic carbon is calculated from two resistivity measurements that are obtained within a fraction of a minute from each other. One of the measurements is taken of the background water resistivity and the other measurement is taken after a sample of the water supply has been subjected to a short period of carbon oxidation. The presented methods allow rapid assessments of total organic carbon in water supplies to be made and determinations of total organic carbon in water supplies when the resistivity of the water supply is changing.

Abstract translation: 提供了用于获得供水中总有机碳总量的方法。 在一种方法中，总有机碳的量根据电阻率测量值与先前确定的所有有机碳完全氧化的水样品的电阻率的比例关系计算。 在另一种方法中，总有机碳的量是通过在彼此之间几分之一分钟内获得的两个电阻率测量来计算的。 测量之一是背景水电阻率，并且在供水样品经受短时间的碳氧化之后进行另一个测量。 所提供的方法可以快速评估供水中的有机碳总量，并确定供水电阻率变化时供水总有机碳的含量。

公开(公告)号：WO1999022234A1

公开(公告)日：1999-05-06

申请号：PCT/GB1997002943

申请日：1997-10-27

Applicant: MILLIPORE CORPORATION ,  PURDOM, Geoffrey, John

Inventor： MILLIPORE CORPORATION

IPC: G01N30/56

CPC classification number: B01D15/22 ,  G01N30/56 ,  G01N30/6004 ,  G01N2030/565

Abstract: A chromatography column at least one central slurry valve (11) positioned at either the top cell assembly and/or the bottom cell assembly. The central slurry valves (11) have a pneumatically actuated valve sleeve (7) which can be shifted to create two different flow configurations. One flow configuration allows for the simultaneous cleaning in place of the flow path used to charge the column (6) with chromatography media (14) and the separate processing of fluid through the chromatography media. The other flow configuration permits the reslurrying and removal of chromatography media from the column, and the subsequent repacking of the column with fresh chromatography media without disassembling the column (6) and the provision of venting of the column (6) in the event of overpressurization during packing.

Abstract translation: 色谱柱，至少一个位于顶部单元组件和/或底部单元组件的中央浆料阀（11）。 中央淤浆阀（11）具有气动致动的阀套（7），其可以移动以产生两种不同的流动构型。 一个流动配置允许同时清洁来代替用色谱介质（14）对色谱柱（6）充电的流动路径，以及通过色谱介质分离处理流体。 另一种流动配置允许色谱介质从色谱柱中重新洗脱和除去，随后用新鲜的色谱介质重新包装色谱柱，而不需要拆卸色谱柱（6），并在超压情况下提供色谱柱（6）排气 包装过程中

公开(公告)号：WO1998009916A1

公开(公告)日：1998-03-12

申请号：PCT/US1997013049

申请日：1997-08-06

Applicant: MILLIPORE CORPORATION

Inventor： MILLIPORE CORPORATION ,  O'NEILL, Gary, A. ,  SIU, Kitty, K. ,  DENONCOURT, Jeffrey, P.

IPC: C02F01/42

CPC classification number: C02F1/444 ,  C02F1/32 ,  C02F1/42 ,  C02F2103/04 ,  Y10S210/90

Abstract: Ultrapure water containing less than 10 ppt total ions, other than hydrogen ion and hydroxide ion is produced by passing deionized water through a system comprising an ultrafiltration step, an oxidizing step where water is exposed to ultraviolet light and ion exchange step. The treated water is recirculated through the oxidizing step and the ion exchange step. Product water from the system can be recovered on a continuous basis so long as the ratio of volume of water circulated within the system to volume of water drawn from the system is at least 10 and preferably at least 20.

Abstract translation: 通过使去离子水通过包含超滤步骤，水暴露于紫外线和离子交换步骤的氧化步骤的系统，产生除氢离子和氢氧根离子以外的小于10ppt总离子的超纯水。 处理过的水通过氧化步骤和离子交换步骤再循环。 系统中的产物水可以连续回收，只要系统内循环的水的体积与从系统抽出的水的体积之比至少为10，优选至少为20。