公开(公告)号：WO2006055748A3

公开(公告)日：2006-09-14

申请号：PCT/US2005041752

申请日：2005-11-17

Applicant: MINRAD INC

Inventor： TERRELL ROSS C ,  LEVINSON JOSHUA A ,  YOUNG CHARLES W

IPC: C07C43/13

CPC classification number: C07C41/22 ,  C07C43/123

Abstract: A method for the preparation of (CF 3 ) 2 CHOCH 2 F (Sevoflurane) is presented, which comprises providing a mixture of (CF 3 ) 2 CHOCH 2 Cl, potassium fluoride, water, and a phase transfer catalyst and reacting the mixture to form (CF 3 ) 2 CHOCH 2 F.

Abstract translation: 提供了一种制备（CF 3 CH 2）CHOCH 2 F（七氟醚）的方法，该方法包括提供（CF 3） 使用氟化钾，水和相转移催化剂，并使混合物反应以形成（CF 3）2 ClCH 3， / SUB>） _{2 CHOCH 2 F。}

公开(公告)号：WO2006113636A3

公开(公告)日：2007-01-18

申请号：PCT/US2006014427

申请日：2006-04-18

Applicant: MINRAD INC

Inventor： TERRELL ROSS C ,  LEVINSON JOSHUA A ,  MCNEIRNEY JOHN C

IPC: C07C41/00

CPC classification number: A61K31/075 ,  C07C41/36 ,  C07C43/123

Abstract: Provided is a sevoflurane anesthetic product which can remain substantially undegraded after long periods of storage, as well as a method for preparing the product. The product comprises sevoflurane in a glass container having a water content of less than 130 ppm. The method comprises drying sevoflurane having a water content of greater than 130 ppm to a water content les than 130 ppm. A preferred method of drying comprises contacting a sevoflurane composition having a water content of greater than 130 ppm with alumina-containing molecular sieves such that the water content is reduced to less than 130 ppm.

Abstract translation: 本发明提供一种七氟醚麻醉剂产品，其长期储存后可保持基本上未降解，以及制备该产品的方法。 该产品在含水量小于130ppm的玻璃容器中包含七氟烷。 该方法包括将水含量大于130ppm的七氟醚干燥至130ppm以下的水含量。 优选的干燥方法包括使具有大于130ppm水含量的七氟烷组合物与含氧化铝的分子筛接触，使得水含量降低至小于130ppm。