公开(公告)号：WO2016118612A8

公开(公告)日：2016-07-28

申请号：PCT/US2016/014108

申请日：2016-01-20

申请人： MIRAGEN THERAPEUTICS, INC.

发明人： DALBY, Christina Marie ,  GALLANT-BEHM, Corrie Lynn ,  JACKSON, Aimee ,  HUTNICK, Kathryn ,  SETO, Anita

IPC分类号： C07H21/04 ,  C12N15/11

摘要： The present invention provides oligonucleotide inhibitors of miR-92 and methods of using said inhibitors for inhibiting the function and/or activity of miR-92 in a subject in need thereof. The present invention also provides methods for evaluating or monitoring the efficacy of a therapeutic for promoting wound healing and selecting a subject for treatment with a therapeutic that modulates miR-92 function and/or activity.

公开(公告)号：WO2016197024A2

公开(公告)日：2016-12-08

申请号：PCT/US2016/035865

申请日：2016-06-03

申请人： MIRAGEN THERAPEUTICS, INC.

发明人： RODMAN, David ,  SETO, Anita ,  DALBY, Christina ,  JACKSON, Aimee ,  BEATTY, Xuan

CPC分类号： C12N15/113 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/344 ,  C12N2320/31 ,  C12N2310/322 ,  C12N2310/3531

摘要： The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such as a T cell lymphoma in a subject by administering to the subject an oligonucleotide inhibitor of miR- 155. The invention also provides methods for reducing or inhibiting the proliferation of malignant T cells by administering an oligonucleotide inhibitor of miR-155.

摘要翻译： 本发明提供miR-155的寡核苷酸抑制剂及其组合物。 本发明还提供了通过向受试者施用miR-155的寡核苷酸抑制剂来治疗受试者中的癌症如T细胞淋巴瘤的方法。本发明还提供了通过施用寡核苷酸抑制剂来减少或抑制恶性T细胞增殖的方法 的miR-155。

公开(公告)号：WO2016118612A3

公开(公告)日：2016-07-28

申请号：PCT/US2016/014108

申请日：2016-01-20

申请人： MIRAGEN THERAPEUTICS, INC.

发明人： DALBY, Christina Marie ,  GALLANT-BEHM, Corrie Lynn ,  JACKSON, Aimee ,  HUTNICK, Kathryn ,  SETO, Anita

IPC分类号： C07H21/04 ,  C12N15/11

摘要： The present invention provides oligonucleotide inhibitors of miR-92 and methods of using said inhibitors for inhibiting the function and/or activity of miR-92 in a subject in need thereof. The present invention also provides methods for evaluating or monitoring the efficacy of a therapeutic for promoting wound healing and selecting a subject for treatment with a therapeutic that modulates miR-92 function and/or activity.

摘要翻译： 本发明提供了miR-92的寡核苷酸抑制剂和使用所述抑制剂在有此需要的受试者中抑制miR-92的功能和/或活性的方法。 本发明还提供了用于评估或监测治疗促进伤口愈合的功效并选择用调节miR-92功能和/或活性的治疗剂治疗的受试者的方法。

公开(公告)号：WO2016118612A2

公开(公告)日：2016-07-28

申请号：PCT/US2016/014108

申请日：2016-01-20

申请人： MIRAGEN THERAPEUTICS, INC.

发明人： DALBY, Christina Marie ,  GALLANT-BEHM, Corrie Lynn ,  JACKSON, Aimee ,  HUTNICK, Kathryn ,  SETO, Anita

CPC分类号： C12N15/113 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/3341

摘要： The present invention provides oligonucleotide inhibitors of miR-92 and methods of using said inhibitors for inhibiting the function and/or activity of miR-92 in a subject in need thereof. The present invention also provides methods for evaluating or monitoring the efficacy of a therapeutic for promoting wound healing and selecting a subject for treatment with a therapeutic that modulates miR-92 function and/or activity.

摘要翻译： 本发明提供miR-92的寡核苷酸抑制剂和使用所述抑制剂抑制有需要的受试者中miR-92的功能和/或活性的方法。 本发明还提供了用于评估或监测用于促进伤口愈合的治疗剂的功效的方法，并且选择受试者用用于调节miR-92功能和/或活性的治疗剂进行治疗。