公开(公告)号：WO2020014526A3

公开(公告)日：2020-01-16

申请号：PCT/US2019/041468

申请日：2019-07-11

Applicant: MOMENTA PHARMACEUTICALS, INC.

Inventor： MANNING, Anthony ,  CHOUDHURY, Amit ,  ORITZ, Daniel ,  LANSING, Jonathan C.

IPC: A61K39/395 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  A61P35/04

Abstract: Fc-antigen binding constructs having a CD38 binding domain and two or more Fc domains are described as are methods for using such constructs. Also described are polypeptides making up such constructs. Fc domain monomers that are included in the constructs can include amino acid substitutions that promote homodimerization or heterodimerization.